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Title: Bismuth generator method

Abstract

A method for separating .sup.213 Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon .sup.213 Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as .sup.225 Ra, .sup.225 Ac, and .sup.221 Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The .sup.213 Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the .sup.213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the .sup.213 Bi. A preferred stripping solution for purification of .sup.213 Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc, to receive the .sup.213 Bi asmore » it is being released from the anion exchange resin.« less

Inventors:
 [1];  [2]
  1. (Richland, WA)
  2. (Pasco, WA)
Issue Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA
OSTI Identifier:
871534
Patent Number(s):
5749042
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
bismuth; generator; method; separating; 213; solution; radionuclides; contains; concentration; chloride; hydrogen; adjusted; allow; formation; complex; brought; contact; anion; exchange; resin; whereupon; absorbed; adhered; non-absorbing; 225; 221; hcl; removed; scrub; washing; stripping; free; reduced; breaks; anionic; releasing; cation; preferred; embodiment; provided; membrane; allowing; extremely; rapid; adherence; purification; medical; applications; sodium; acetate; ph; protein; conjugated; bifunctional; chelating; agents; vivo; naoac; receive; released; bifunctional chelating; stripping solution; medical applications; anion exchange; exchange resin; preferred embodiment; chelating agents; chelating agent; sodium acetate; scrub solution; solution contains; chloride complex; extremely rapid; anionic complex; /423/210/376/

Citation Formats

Bray, Lane Allan, and DesChane, Jaquetta R. Bismuth generator method. United States: N. p., 1998. Web.
Bray, Lane Allan, & DesChane, Jaquetta R. Bismuth generator method. United States.
Bray, Lane Allan, and DesChane, Jaquetta R. Thu . "Bismuth generator method". United States. https://www.osti.gov/servlets/purl/871534.
@article{osti_871534,
title = {Bismuth generator method},
author = {Bray, Lane Allan and DesChane, Jaquetta R.},
abstractNote = {A method for separating .sup.213 Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon .sup.213 Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as .sup.225 Ra, .sup.225 Ac, and .sup.221 Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The .sup.213 Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the .sup.213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the .sup.213 Bi. A preferred stripping solution for purification of .sup.213 Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc, to receive the .sup.213 Bi as it is being released from the anion exchange resin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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