Identification of cell density signal molecule
Abstract
Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.
- Inventors:
-
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 871485
- Patent Number(s):
- 5741895
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- identification; cell; density; signal; molecule; disclosed; novel; proteinaceous; cds; 25; 35; kd; secreted; fibroblastic; primary; avian; tendon; cells; culture; causes; self-regulate; proliferation; expression; differentiated; function; effects; increase; procollagen; production; cultures; fold; rates; decreased; antibodies; recognize; diagnostics; treatments; injuries; diseases; involving; connective; tissues; particularly; methods; cell density; cell culture; signal molecule; density signal; cell cultures; proteinaceous cell; novel proteinaceous; tendon cells; tendon cell; /530/
Citation Formats
Schwarz, Richard I. Identification of cell density signal molecule. United States: N. p., 1998.
Web.
Schwarz, Richard I. Identification of cell density signal molecule. United States.
Schwarz, Richard I. Thu .
"Identification of cell density signal molecule". United States. https://www.osti.gov/servlets/purl/871485.
@article{osti_871485,
title = {Identification of cell density signal molecule},
author = {Schwarz, Richard I},
abstractNote = {Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}
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