Identification of cell density signal molecule

Title: Identification of cell density signal molecule

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Abstract

Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.

Inventors:

Schwarz, Richard I. ^[1]

(Oakland, CA)

Issue Date:: 1998-01-01

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

OSTI Identifier:: 871485

Patent Number(s):: 5741895

Assignee:: Regents of University of California (Oakland, CA) LBNL

DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: identification; cell; density; signal; molecule; disclosed; novel; proteinaceous; cds; 25; 35; kd; secreted; fibroblastic; primary; avian; tendon; cells; culture; causes; self-regulate; proliferation; expression; differentiated; function; effects; increase; procollagen; production; cultures; fold; rates; decreased; antibodies; recognize; diagnostics; treatments; injuries; diseases; involving; connective; tissues; particularly; methods; cell density; cell culture; signal molecule; density signal; cell cultures; proteinaceous cell; novel proteinaceous; tendon cells; tendon cell; /530/

Citation Formats


                    Schwarz, Richard I. Identification of cell density signal molecule.  United States: N. p., 1998. 
        Web.

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                    Schwarz, Richard I. Identification of cell density signal molecule.  United States.

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                    Schwarz, Richard I. Thu .  
        "Identification of cell density signal molecule".  United States.  https://www.osti.gov/servlets/purl/871485.

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@article{osti_871485,

  title        = {Identification of cell density signal molecule},

  author       = {Schwarz, Richard I.},

  abstractNote = {Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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