Identification of cell density signal molecule

Schwarz, Richard I

Title: Identification of cell density signal molecule

Abstract

Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.

Inventors:

Schwarz, Richard I ^[1]

Oakland, CA

Issue Date:: 1998-04-21

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 871485

Patent Number(s):: 5741895

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/475 - Growth factors

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S530/84 - Bones

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: identification; cell; density; signal; molecule; disclosed; novel; proteinaceous; cds; 25; 35; kd; secreted; fibroblastic; primary; avian; tendon; cells; culture; causes; self-regulate; proliferation; expression; differentiated; function; effects; increase; procollagen; production; cultures; fold; rates; decreased; antibodies; recognize; diagnostics; treatments; injuries; diseases; involving; connective; tissues; particularly; methods; cell density; cell culture; signal molecule; density signal; cell cultures; proteinaceous cell; novel proteinaceous; tendon cells; tendon cell; /530/

Citation Formats


                    Schwarz, Richard I. Identification of cell density signal molecule.  United States: N. p., 1998. 
        Web.

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                    Schwarz, Richard I. Identification of cell density signal molecule.  United States.

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                    Schwarz, Richard I. Tue .  
        "Identification of cell density signal molecule".  United States.  https://www.osti.gov/servlets/purl/871485.

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@article{osti_871485,

  title        = {Identification of cell density signal molecule},

  author       = {Schwarz, Richard I},

  abstractNote = {Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {4}

}

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Works referenced in this record:

A simple fractionation of chicken egg yolk yields a protein component that stimulates cell proliferation and differentiation in primary avian tendon cells
journal, May 1986

Martis, Missie Joe; Schwarz, Richard I.
In Vitro Cellular & Developmental Biology, Vol. 22, Issue 5
https://doi.org/10.1007/BF02621225

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Title: Identification of cell density signal molecule

Abstract

Citation Formats

A simple fractionation of chicken egg yolk yields a protein component that stimulates cell proliferation and differentiation in primary avian tendon cells journal, May 1986

A simple fractionation of chicken egg yolk yields a protein component that stimulates cell proliferation and differentiation in primary avian tendon cells
journal, May 1986