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Title: Ultrashort pulse high repetition rate laser system for biological tissue processing

Abstract

A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [4];  [4];  [4]
  1. Laguna Beach, CA
  2. Danville, CA
  3. Moss Beach, CA
  4. Livermore, CA
  5. Fremont, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
871382
Patent Number(s):
5720894
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61C - DENTISTRY
B - PERFORMING OPERATIONS B23 - MACHINE TOOLS B23K - SOLDERING OR UNSOLDERING
DOE Contract Number:  
FG03-91ER61227
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
ultrashort; pulse; repetition; rate; laser; biological; tissue; processing; method; apparatus; disclosed; fast; efficient; precise; damage-free; removal; duration; operating; rates; fs; 50; energy; deposition; localized; depth; occurs; significant; hydrodynamic; motion; thermal; conduction; leading; collateral; damage; material; removed; micrometer; minimal; mechanical; effects; associated; ablation; allows; operation; region; 10; 1000; hertz; achieves; input; ablated; volume; density; required; ablate; decreases; decreasing; width; threshold; weakly; dependent; type; condition; allowing; maximum; flexibility; various; applications; chirped-pulse; amplified; titanium-doped; sapphire; source; embodiment; repetition rates; energy density; pulse repetition; repetition rate; pulse width; laser pulse; laser energy; pulse duration; energy deposition; biological tissue; method allows; rate laser; rate operation; thermal conduction; various biological; minimal thermal; input laser; material removed; sapphire laser; removal rates; removal rate; ultrashort pulse; method allow; ablate material; material removal; /216/156/606/607/

Citation Formats

Neev, Joseph, Da Silva, Luiz B, Matthews, Dennis L, Glinsky, Michael E, Stuart, Brent C, Perry, Michael D, Feit, Michael D, and Rubenchik, Alexander M. Ultrashort pulse high repetition rate laser system for biological tissue processing. United States: N. p., 1998. Web.
Neev, Joseph, Da Silva, Luiz B, Matthews, Dennis L, Glinsky, Michael E, Stuart, Brent C, Perry, Michael D, Feit, Michael D, & Rubenchik, Alexander M. Ultrashort pulse high repetition rate laser system for biological tissue processing. United States.
Neev, Joseph, Da Silva, Luiz B, Matthews, Dennis L, Glinsky, Michael E, Stuart, Brent C, Perry, Michael D, Feit, Michael D, and Rubenchik, Alexander M. Thu . "Ultrashort pulse high repetition rate laser system for biological tissue processing". United States. https://www.osti.gov/servlets/purl/871382.
@article{osti_871382,
title = {Ultrashort pulse high repetition rate laser system for biological tissue processing},
author = {Neev, Joseph and Da Silva, Luiz B and Matthews, Dennis L and Glinsky, Michael E and Stuart, Brent C and Perry, Michael D and Feit, Michael D and Rubenchik, Alexander M},
abstractNote = {A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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Works referenced in this record:

Nanosecond and femtosecond excimer laser ablation of fused silica
journal, April 1992


Laser-Induced Damage in Dielectrics with Nanosecond to Subpicosecond Pulses
journal, March 1995


Scanning electron microscopy and thermal characteristics of dentin ablated by a short-pulse XeCl excimer laser
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Time resolved dynamics of subpicosecond laser ablation
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conference, September 1994


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Effect of water content on UV and IR hard tissue ablation
conference, January 1995


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Influence of the laser-spot diameter on photo-ablation rates
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Ablation of hard dental tissues with an ArF-pulsed excimer laser
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  • Neev, Joseph; Raney, Daniel; Whalen, William E.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings
  • https://doi.org/10.1117/12.44100

Application of ultrashort laser pulses in dentistry
conference, December 1993


Plasma-mediated ablation of brain tissue with picosecond laser pulses
journal, June 1994


Femtosecond-pulse laser ablation of human corneas
journal, May 1994