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Title: Methodology and apparatus for diffuse photon mimaging

Abstract

Non-invasive near infrared optical medical imaging devices for both hematoma detection in the brain and early tumor detection in the breast is achieved using image reconstruction which allows a mapping of the position dependent contrast diffusive propagation constants, which are related to the optical absorption coefficient and scattering coefficient in the tissue, at near infrared wavelengths. Spatial resolutions in the range of 5 mm for adult brain sizes and breast sizes can be achieved. The image reconstruction utilizes WKB approximation on most probable diffusion paths which has as lowest order approximation the straight line-of-sight between the plurality of sources and the plurality of detectors. The WKB approximation yields a set of linear equations in which the contrast optical absorption coefficients are the unknowns and for which signals can be generated to produce a pixel map of the contrast optical resolution of the scanned tissue.

Inventors:
 [1];  [1];  [1]
  1. (Los Angeles, CA)
Issue Date:
Research Org.:
University of California
Sponsoring Org.:
USDOE - Office of Energy Research (ER)
OSTI Identifier:
871264
Patent Number(s):
5694938
Assignee:
Regents of University of California (Oakland, CA) OAK
DOE Contract Number:  
FG03-88ER45378
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
methodology; apparatus; diffuse; photon; mimaging; non-invasive; near; infrared; optical; medical; imaging; devices; hematoma; detection; brain; tumor; breast; achieved; image; reconstruction; allows; mapping; position; dependent; contrast; diffusive; propagation; constants; related; absorption; coefficient; scattering; tissue; wavelengths; spatial; resolutions; range; adult; sizes; utilizes; wkb; approximation; probable; diffusion; paths; lowest; straight; line-of-sight; plurality; sources; detectors; yields; set; linear; equations; coefficients; unknowns; signals; generated; produce; pixel; map; resolution; scanned; imaging devices; near infrared; optical absorption; imaging device; spatial resolution; absorption coefficient; propagation constant; medical imaging; image reconstruction; straight line; /600/

Citation Formats

Feng, Shechao C., Zeng, Fanan, and Zhao, Hui-Lin. Methodology and apparatus for diffuse photon mimaging. United States: N. p., 1997. Web.
Feng, Shechao C., Zeng, Fanan, & Zhao, Hui-Lin. Methodology and apparatus for diffuse photon mimaging. United States.
Feng, Shechao C., Zeng, Fanan, and Zhao, Hui-Lin. Tue . "Methodology and apparatus for diffuse photon mimaging". United States. https://www.osti.gov/servlets/purl/871264.
@article{osti_871264,
title = {Methodology and apparatus for diffuse photon mimaging},
author = {Feng, Shechao C. and Zeng, Fanan and Zhao, Hui-Lin},
abstractNote = {Non-invasive near infrared optical medical imaging devices for both hematoma detection in the brain and early tumor detection in the breast is achieved using image reconstruction which allows a mapping of the position dependent contrast diffusive propagation constants, which are related to the optical absorption coefficient and scattering coefficient in the tissue, at near infrared wavelengths. Spatial resolutions in the range of 5 mm for adult brain sizes and breast sizes can be achieved. The image reconstruction utilizes WKB approximation on most probable diffusion paths which has as lowest order approximation the straight line-of-sight between the plurality of sources and the plurality of detectors. The WKB approximation yields a set of linear equations in which the contrast optical absorption coefficients are the unknowns and for which signals can be generated to produce a pixel map of the contrast optical resolution of the scanned tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {12}
}

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