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Title: Diagnostic method employing MSH2 nucleic acids

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
Inventors:
 [1];  [2];  [2]
  1. (Helsingfors, FI)
  2. (Baltimore, MD)
Issue Date:
OSTI Identifier:
871256
Assignee:
Johns Hopkins University (Baltimore, MD) CHO
Patent Number(s):
US 5693470
Contract Number:
FG02-91ER61139
Research Org:
Eleanor Roosevelt Institute
Country of Publication:
United States
Language:
English
Subject:
diagnostic; method; employing; msh2; nucleic; acids; human; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; diagnostic method; hereditary non-polyposis; nucleic acid; nucleic acids; tumor cells; replication error; mismatch repair; method employing; human msh2; germ line; dna mismatch; line mutations; employing msh2; method employ; /435/999/

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