Diagnostic method employing MSH2 nucleic acids
Abstract
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
- Inventors:
-
- Helsingfors, FI
- Baltimore, MD
- Issue Date:
- Research Org.:
- Eleanor Roosevelt Institute
- OSTI Identifier:
- 871256
- Patent Number(s):
- 5693470
- Assignee:
- Johns Hopkins University (Baltimore, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-91ER61139
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- diagnostic; method; employing; msh2; nucleic; acids; human; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; diagnostic method; hereditary non-polyposis; nucleic acid; nucleic acids; tumor cells; replication error; mismatch repair; method employing; human msh2; germ line; dna mismatch; line mutations; employing msh2; method employ; /435/999/
Citation Formats
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Diagnostic method employing MSH2 nucleic acids. United States: N. p., 1997.
Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Diagnostic method employing MSH2 nucleic acids. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Wed .
"Diagnostic method employing MSH2 nucleic acids". United States. https://www.osti.gov/servlets/purl/871256.
@article{osti_871256,
title = {Diagnostic method employing MSH2 nucleic acids},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}
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