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Title: Probes labelled with energy transfer coupled dyes

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
Inventors:
 [1];  [2];  [3]
  1. (El Cerrito, CA)
  2. (Orinda, CA)
  3. (Berkeley, CA)
Issue Date:
OSTI Identifier:
871235
Assignee:
Regents of University of California (Oakland, CA) OAK
Patent Number(s):
US 5688648
Contract Number:
FG03-91ER61125
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
probes; labelled; energy; transfer; coupled; dyes; compositions; provided; comprising; sets; fluorescent; labels; carrying; pairs; donor; acceptor; dye; molecules; designed; efficient; excitation; donors; single; wavelength; emission; wavelengths; donor-acceptor; modified; substantially; mobility; separation; conditions; varying; distance; pair; particularly; sequencing; nucleic; acids; energy transfer; nucleic acid; provided comprising; nucleic acids; dye molecules; separation conditions; fluorescent labels; single wavelength; comprising sets; fluorescent composition; acceptor pair; carrying pairs; acceptor dye; efficient excitation; labels carrying; /435/