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Title: Thermostable cellulase from a thermomonospora gene

Abstract

The invention relates to a gene isolated from Thermomonospora fusca, wherein the gene encodes a thermostable cellulase. Disclosed is the nucleotide sequence of the T. fusca gene; and nucleic acid molecules comprising the gene, or a fragment of the gene, that can be used to recombinantly express the cellulase or a catalytically active polypeptide thereof, respectively. The isolated and purified recombinant cellulase or catalytically active polypeptide may be used to hydrolyze substrate either by itself; or in combination with other cellulases, with the resultant combination having unexpected hydrolytic activity.

Inventors:
 [1];  [1];  [1]
  1. (Ithaca, NY)
Issue Date:
Research Org.:
Cornell University
OSTI Identifier:
871182
Patent Number(s):
5677151
Application Number:
08/265429
Assignee:
Cornell Research Foundation, Inc. (Ithaca, NY) CHO
DOE Contract Number:  
FG02-84ER13233
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
thermostable; cellulase; thermomonospora; relates; isolated; fusca; encodes; disclosed; nucleotide; sequence; nucleic; acid; molecules; comprising; fragment; recombinantly; express; catalytically; active; polypeptide; respectively; purified; recombinant; hydrolyze; substrate; combination; cellulases; resultant; unexpected; hydrolytic; activity; acid molecule; nucleotide sequence; acid molecules; nucleic acid; catalytically active; molecules comprising; thermostable cellulase; active poly; active polypeptide; /435/424/999/

Citation Formats

Wilson, David B., Walker, Larry P., and Zhang, Sheng. Thermostable cellulase from a thermomonospora gene. United States: N. p., 1997. Web.
Wilson, David B., Walker, Larry P., & Zhang, Sheng. Thermostable cellulase from a thermomonospora gene. United States.
Wilson, David B., Walker, Larry P., and Zhang, Sheng. Tue . "Thermostable cellulase from a thermomonospora gene". United States. https://www.osti.gov/servlets/purl/871182.
@article{osti_871182,
title = {Thermostable cellulase from a thermomonospora gene},
author = {Wilson, David B. and Walker, Larry P. and Zhang, Sheng},
abstractNote = {The invention relates to a gene isolated from Thermomonospora fusca, wherein the gene encodes a thermostable cellulase. Disclosed is the nucleotide sequence of the T. fusca gene; and nucleic acid molecules comprising the gene, or a fragment of the gene, that can be used to recombinantly express the cellulase or a catalytically active polypeptide thereof, respectively. The isolated and purified recombinant cellulase or catalytically active polypeptide may be used to hydrolyze substrate either by itself; or in combination with other cellulases, with the resultant combination having unexpected hydrolytic activity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {10}
}

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