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Title: Miniaturized flow injection analysis system

A chemical analysis technique known as flow injection analysis, wherein small quantities of chemical reagents and sample are intermixed and reacted within a capillary flow system and the reaction products are detected optically, electrochemically, or by other means. A highly miniaturized version of a flow injection analysis system has been fabricated utilizing microfabrication techniques common to the microelectronics industry. The microflow system uses flow capillaries formed by etching microchannels in a silicon or glass wafer followed by bonding to another wafer, commercially available microvalves bonded directly to the microflow channels, and an optical absorption detector cell formed near the capillary outlet, with light being both delivered and collected with fiber optics. The microflow system is designed mainly for analysis of liquids and currently measures 38.times.25.times.3 mm, but can be designed for gas analysis and be substantially smaller in construction.
Inventors:
 [1]
  1. (Livermore, CA)
Issue Date:
OSTI Identifier:
871029
Assignee:
Regents of University of California (Oakland, CA) LLNL
Patent Number(s):
US 5644395
Contract Number:
W-7405-ENG-48
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Country of Publication:
United States
Language:
English
Subject:
miniaturized; flow; injection; analysis; chemical; technique; quantities; reagents; sample; intermixed; reacted; capillary; reaction; products; detected; optically; electrochemically; means; highly; version; fabricated; utilizing; microfabrication; techniques; common; microelectronics; industry; microflow; capillaries; formed; etching; microchannels; silicon; glass; wafer; followed; bonding; commercially; available; microvalves; bonded; directly; channels; optical; absorption; detector; cell; near; outlet; light; delivered; collected; fiber; optics; designed; mainly; liquids; currently; measures; 38; times; 25; gas; substantially; construction; gas analysis; flow injection; optical absorption; chemical analysis; fiber optics; flow channels; flow channel; fiber optic; reaction product; reaction products; commercially available; fabrication techniques; absorption detector; chemical reagent; detector cell; injection analysis; analysis technique; cell formed; chemical reagents; capillary flow; /356/