Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
Abstract
Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
- Inventors:
-
- 2101 B. Ulster Pl., Coram, NY 11727
- 460 Harrison Ave., Miller Pl., NY 11764
- 16 Seville Ln., Stony Brook, NY 11790
- 8 Penelope Dr., Setauket, NY 11733
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 870978
- Patent Number(s):
- 5635157
- Application Number:
- 08/132,201
- Assignee:
- Mease, Ronnie C. (2101 B. Ulster Pl., Coram, NY 11727);Kolsky, Kathryn L. (460 Harrison Ave., Miller Pl., NY 11764);Mausner, Leonard F. (16 Seville Ln., Stony Brook, NY 11790);Srivastava, Suresh C. (8 Penelope Dr., Setauket, NY 11733)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclohexyl; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /424/530/999/
Citation Formats
Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, and Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States: N. p., 1997.
Web.
Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, & Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States.
Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, and Srivastava, Suresh C. Tue .
"Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging". United States. https://www.osti.gov/servlets/purl/870978.
@article{osti_870978,
title = {Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging},
author = {Mease, Ronnie C and Kolsky, Kathryn L and Mausner, Leonard F and Srivastava, Suresh C},
abstractNote = {Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {6}
}
Works referenced in this record:
Preface
journal, December 1993
- Colton, Ted; Freedman, Laurence; Johnson, Tony
- Statistics in Medicine, Vol. 12, Issue 24