Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Mease, Ronnie C; Kolsky, Kathryn L; Mausner, Leonard F; Srivastava, Suresh C

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Title: Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Abstract

Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

Inventors:

Mease, Ronnie C ^[1]; Kolsky, Kathryn L ^[2]; Mausner, Leonard F ^[3]; Srivastava, Suresh C ^[4]

2101 B. Ulster Pl., Coram, NY 11727
460 Harrison Ave., Miller Pl., NY 11764
16 Seville Ln., Stony Brook, NY 11790
8 Penelope Dr., Setauket, NY 11733

Issue Date:: 1997-06-03

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 870978

Patent Number(s):: 5635157

Application Number:: 08/132,201

Assignee:: Mease, Ronnie C. (2101 B. Ulster Pl., Coram, NY 11727);Kolsky, Kathryn L. (460 Harrison Ave., Miller Pl., NY 11764);Mausner, Leonard F. (16 Seville Ln., Stony Brook, NY 11790);Srivastava, Suresh C. (8 Penelope Dr., Setauket, NY 11733)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/1093 - {conjugates with carriers being antibodies}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C233/41 - with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
C07C2601/16 - the ring being unsaturated

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/534 - with radioactive label

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DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclohexyl; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /424/530/999/

Citation Formats


                    Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, and Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging.  United States: N. p., 1997. 
        Web.

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                    Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, & Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging.  United States.

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                    Mease, Ronnie C, Kolsky, Kathryn L, Mausner, Leonard F, and Srivastava, Suresh C. Tue .  
        "Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging".  United States.  https://www.osti.gov/servlets/purl/870978.

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@article{osti_870978,

  title        = {Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging},

  author       = {Mease, Ronnie C and Kolsky, Kathryn L and Mausner, Leonard F and Srivastava, Suresh C},

  abstractNote = {Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {6}

}

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Works referenced in this record:

Preface
journal, December 1993

Colton, Ted; Freedman, Laurence; Johnson, Tony
Statistics in Medicine, Vol. 12, Issue 24
https://doi.org/10.1002/sim.4780122402

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Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

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Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings
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Similar Records

Title: Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Abstract

Citation Formats

Preface journal, December 1993

Preface
journal, December 1993