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Title: Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Abstract

Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

Inventors:
 [1];  [2];  [3];  [4]
  1. (2101 B. Ulster Pl., Coram, NY 11727)
  2. (460 Harrison Ave., Miller Pl., NY 11764)
  3. (16 Seville Ln., Stony Brook, NY 11790)
  4. (8 Penelope Dr., Setauket, NY 11733)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
870978
Patent Number(s):
5635157
Application Number:
08/132,201
Assignee:
Mease, Ronnie C. (2101 B. Ulster Pl., Coram, NY 11727);Kolsky, Kathryn L. (460 Harrison Ave., Miller Pl., NY 11764);Mausner, Leonard F. (16 Seville Ln., Stony Brook, NY 11790);Srivastava, Suresh C. (8 Penelope Dr., Setauket, NY 11733) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclohexyl; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /424/530/999/

Citation Formats

Mease, Ronnie C., Kolsky, Kathryn L., Mausner, Leonard F., and Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States: N. p., 1997. Web.
Mease, Ronnie C., Kolsky, Kathryn L., Mausner, Leonard F., & Srivastava, Suresh C. Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States.
Mease, Ronnie C., Kolsky, Kathryn L., Mausner, Leonard F., and Srivastava, Suresh C. Tue . "Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging". United States. https://www.osti.gov/servlets/purl/870978.
@article{osti_870978,
title = {Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging},
author = {Mease, Ronnie C. and Kolsky, Kathryn L. and Mausner, Leonard F. and Srivastava, Suresh C.},
abstractNote = {Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {6}
}

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