skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Abstract

Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

Inventors:
 [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
870921
Patent Number(s):
5624794
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; extending; useful; shelf-life; refrigerated; blood; cells; flushing; inert; gas; oxygen; removal; cost-effective; degree; storage; procedure; preserves; cell; quality; prolongs; post-transfusion; vivo; survival; described; preservation; adenosine; triphosphate; levels; reduction; hemolysis; membrane; vesicle; production; stored; prolonged; periods; time; achieved; removing; therefrom; particular; boosted; samples; addition; ammonium; phosphate; blood cells; inert gas; ammonium phosphate; blood cell; prolonged period; removing oxygen; oxygen removal; useful shelf-life; prolonged periods; storage procedure; cell quality; /435/604/

Citation Formats

Bitensky, Mark W, and Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas. United States: N. p., 1997. Web.
Bitensky, Mark W, & Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas. United States.
Bitensky, Mark W, and Yoshida, Tatsuro. Wed . "Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas". United States. https://www.osti.gov/servlets/purl/870921.
@article{osti_870921,
title = {Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas},
author = {Bitensky, Mark W and Yoshida, Tatsuro},
abstractNote = {Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Studies in Red Blood Cell Preservation
journal, July 1993


A moment problem with respect toC *-Algebras
journal, September 1983


Effects of Oxygen on Red Cells during Liquid Storage at +4°C
journal, July 1986