Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Bitensky, Mark W; Yoshida, Tatsuro

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Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Abstract

Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

Inventors:

Bitensky, Mark W ^[1]; Yoshida, Tatsuro ^[1]

Los Alamos, NM

Issue Date:: 1997-01-01

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

OSTI Identifier:: 870921

Patent Number(s):: 5624794

Assignee:: Regents of University of California (Los Alamos, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
A01N1/02 - Preservation of living parts
A01N1/0226 - {Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients}

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; extending; useful; shelf-life; refrigerated; blood; cells; flushing; inert; gas; oxygen; removal; cost-effective; degree; storage; procedure; preserves; cell; quality; prolongs; post-transfusion; vivo; survival; described; preservation; adenosine; triphosphate; levels; reduction; hemolysis; membrane; vesicle; production; stored; prolonged; periods; time; achieved; removing; therefrom; particular; boosted; samples; addition; ammonium; phosphate; blood cells; inert gas; ammonium phosphate; blood cell; prolonged period; removing oxygen; oxygen removal; useful shelf-life; prolonged periods; storage procedure; cell quality; /435/604/

Citation Formats


                    Bitensky, Mark W, and Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas.  United States: N. p., 1997. 
        Web.

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                    Bitensky, Mark W, & Yoshida, Tatsuro. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas.  United States.

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                    Bitensky, Mark W, and Yoshida, Tatsuro. Wed .  
        "Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas".  United States.  https://www.osti.gov/servlets/purl/870921.

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@article{osti_870921,

  title        = {Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas},

  author       = {Bitensky, Mark W and Yoshida, Tatsuro},

  abstractNote = {Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1997},

  month        = {1}

}

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Works referenced in this record:

Studies in Red Blood Cell Preservation
journal, July 1993

Greenwalt, T. J.; Dumaswala, U. J.; Dhingra, N.
Vox Sanguinis, Vol. 65, Issue 2
https://doi.org/10.1111/j.1423-0410.1993.tb02122.x

A moment problem with respect toC *-Algebras
journal, September 1983

Sebestyén, Z.
Acta Mathematica Hungarica, Vol. 42, Issue 3-4
https://doi.org/10.1007/BF01956780

Effects of Oxygen on Red Cells during Liquid Storage at +4°C
journal, July 1986

Högman, Claes F.; Verdier, Carl-Henric; Ericson, Åke
Vox Sanguinis, Vol. 51, Issue 1
https://doi.org/10.1111/j.1423-0410.1986.tb00204.x

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Similar Records

Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Abstract

Citation Formats

Studies in Red Blood Cell Preservation journal, July 1993

A moment problem with respect toC *-Algebras journal, September 1983

Effects of Oxygen on Red Cells during Liquid Storage at +4°C journal, July 1986

Studies in Red Blood Cell Preservation
journal, July 1993

A moment problem with respect toC *-Algebras
journal, September 1983

Effects of Oxygen on Red Cells during Liquid Storage at +4°C
journal, July 1986