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Title: Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.
Inventors:
 [1];  [1]
  1. (Los Alamos, NM)
Issue Date:
OSTI Identifier:
870921
Assignee:
Regents of University of California (Los Alamos, NM) LANL
Patent Number(s):
US 5624794
Contract Number:
W-7405-ENG-36
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM
Country of Publication:
United States
Language:
English
Subject:
method; extending; useful; shelf-life; refrigerated; blood; cells; flushing; inert; gas; oxygen; removal; cost-effective; degree; storage; procedure; preserves; cell; quality; prolongs; post-transfusion; vivo; survival; described; preservation; adenosine; triphosphate; levels; reduction; hemolysis; membrane; vesicle; production; stored; prolonged; periods; time; achieved; removing; therefrom; particular; boosted; samples; addition; ammonium; phosphate; blood cells; inert gas; ammonium phosphate; blood cell; prolonged period; removing oxygen; oxygen removal; useful shelf-life; prolonged periods; storage procedure; cell quality; /435/604/