DNA polymerase having modified nucleotide binding site for DNA sequencing
Abstract
Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.
- Inventors:
-
- Cambridge, MA
- Chestnut Hill, MA
- Issue Date:
- Research Org.:
- Harvard University
- OSTI Identifier:
- 870881
- Patent Number(s):
- 5614365
- Assignee:
- President & Fellow of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-88ER60688
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- dna; polymerase; modified; nucleotide; binding; site; sequencing; encoding; incorporates; dideoxynucleotides; 20-fold; compared; corresponding; deoxynucleotides; naturally-occurring; dna polymerase; binding site; dna sequencing; modified polymer; /435/530/999/
Citation Formats
Tabor, Stanley, and Richardson, Charles. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States: N. p., 1997.
Web.
Tabor, Stanley, & Richardson, Charles. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States.
Tabor, Stanley, and Richardson, Charles. Wed .
"DNA polymerase having modified nucleotide binding site for DNA sequencing". United States. https://www.osti.gov/servlets/purl/870881.
@article{osti_870881,
title = {DNA polymerase having modified nucleotide binding site for DNA sequencing},
author = {Tabor, Stanley and Richardson, Charles},
abstractNote = {Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}
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