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Title: DNA polymerase having modified nucleotide binding site for DNA sequencing

Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.
Inventors:
 [1];  [2]
  1. (Cambridge, MA)
  2. (Chestnut Hill, MA)
Issue Date:
OSTI Identifier:
870881
Assignee:
President & Fellow of Harvard College (Cambridge, MA) CHO
Patent Number(s):
US 5614365
Contract Number:
FG02-88ER60688
Research Org:
Harvard University
Country of Publication:
United States
Language:
English
Subject:
dna; polymerase; modified; nucleotide; binding; site; sequencing; encoding; incorporates; dideoxynucleotides; 20-fold; compared; corresponding; deoxynucleotides; naturally-occurring; dna polymerase; binding site; dna sequencing; modified polymer; /435/530/999/