Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells
Abstract
An apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis thereof.
- Inventors:
-
- 12508 Loyola, NE., Albuquerque, NM 87112
- 7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 870852
- Patent Number(s):
- 5608519
- Assignee:
- Gourley, Paul L. (12508 Loyola, NE., Albuquerque, NM 87112);Gourley, Mark F. (7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- laser; apparatus; method; microscopic; spectroscopic; analysis; processing; biological; cells; comprises; region; cavity; containing; analyzed; presence; cell; superposition; activated; portion; medium; encode; information; beam; recoverable; means; preferably; array; photodetector; ccd; camera; spectrometer; analyze; biomedical; including; blood; manipulating; sorting; eradicating; analysis region; ccd camera; spectroscopic analysis; laser cavity; blood cells; apparatus comprises; laser beam; biological cells; laser apparatus; processing means; blood cell; apparatus comprise; activated portion; biological cell; /356/250/
Citation Formats
Gourley, Paul L, and Gourley, Mark F. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. United States: N. p., 1997.
Web.
Gourley, Paul L, & Gourley, Mark F. Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. United States.
Gourley, Paul L, and Gourley, Mark F. Wed .
"Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells". United States. https://www.osti.gov/servlets/purl/870852.
@article{osti_870852,
title = {Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells},
author = {Gourley, Paul L and Gourley, Mark F},
abstractNote = {An apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}
Works referenced in this record:
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conference, June 1993
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journal, September 1992
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Optical trapping and manipulation of single cells using infrared laser beams
journal, December 1987
- Ashkin, A.; Dziedzic, J. M.; Yamane, T.
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