Human MSH2 protein
Abstract
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
- Inventors:
-
- Helsingfors, FI
- Baltimore, MD
- Issue Date:
- Research Org.:
- Eleanor Roosevelt Institute
- OSTI Identifier:
- 870772
- Patent Number(s):
- 5591826
- Assignee:
- Johns Hopkins University (Baltimore, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- FG02-91ER61139
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- human; msh2; protein; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; hereditary non-polyposis; tumor cells; replication error; mismatch repair; human msh2; germ line; msh2 protein; dna mismatch; line mutations; /530/
Citation Formats
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Human MSH2 protein. United States: N. p., 1997.
Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Human MSH2 protein. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Wed .
"Human MSH2 protein". United States. https://www.osti.gov/servlets/purl/870772.
@article{osti_870772,
title = {Human MSH2 protein},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
journal, September 1993
- Strand, Micheline; Prolla, Tomas A.; Liskay, R. Michael
- Nature, Vol. 365, Issue 6443
Hypermutability and mismatch repair deficiency in RER+ tumor cells
journal, December 1993
- Parsons, Ramon; Li, Guo-Min; Longley, Matthew J.
- Cell, Vol. 75, Issue 6
Microsatellite instability in cancer of the proximal colon
journal, May 1993
- Thibodeau, S.; Bren, G.; Schaid, D.
- Science, Vol. 260, Issue 5109
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
journal, December 1993
- Fishel, Richard; Lescoe, Mary Kay; Rao, M. R. S.
- Cell, Vol. 75, Issue 5
Genetic mapping of a locus predisposing to human colorectal cancer
journal, May 1993
- Peltomaki, P.; Aaltonen, L.; Sistonen, P.
- Science, Vol. 260, Issue 5109
Clues to the pathogenesis of familial colorectal cancer
journal, May 1993
- Aaltonen, L.; Peltomaki, P.; Leach, F.
- Science, Vol. 260, Issue 5109