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Title: Human MSH2 protein

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
 [1];  [2];  [2]
  1. (Helsingfors, FI)
  2. (Baltimore, MD)
Issue Date:
OSTI Identifier:
Johns Hopkins University (Baltimore, MD) CHO
Patent Number(s):
US 5591826
Contract Number:
Research Org:
Eleanor Roosevelt Institute
Country of Publication:
United States
human; msh2; protein; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; hereditary non-polyposis; tumor cells; replication error; mismatch repair; human msh2; germ line; msh2 protein; dna mismatch; line mutations; /530/