Title: Method for protection against genotoxic mutagenesis

Abstract

A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.

Inventors:

Grdina, David J ^[1]

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1. Naperville, IL

Issue Date:

1996-01-01

Research Org.:

Argonne National Laboratory (ANL), Argonne, IL (United States)

OSTI Identifier:

870650

Patent Number(s):

5567686

Assignee:

Arch Development Corporation (Chicago, IL)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/13 - Amines {
A61K31/185 - Acids
A61K31/425 - Thiazoles
A61K31/66 - Phosphorus compounds
A61K31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00 - Antineoplastic agents
A61P39/00 - General protective or antinoxious agents
A61P39/02 - Antidotes
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C323/25 - the carbon skeleton being acyclic and saturated

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F9/1651 - {with hydroxyalkyl compounds with further substituents on alkyl}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C07H5/10 - to sulfur
C07H9/06 - the hetero ring containing nitrogen as ring hetero atoms

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DOE Contract Number:  

W-31109-ENG-38

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; mutational; damage; mammalian; cells; irrespective; nature; mutagenic; event; source; radiational; chemical; insult; mammalian cells; chemical insult; mutational damage; mutagenic event; genotoxic mutagenesis; /514/