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Title: Self-assembling multimeric nucleic acid constructs

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.
Inventors:
 [1];  [2];  [1];  [1];  [3];  [4]
  1. (Boston, MA)
  2. (Bremen, DE)
  3. (Brookline, MA)
  4. (Southborough, MA)
Issue Date:
OSTI Identifier:
870622
Assignee:
Trustees of Boston University (Boston, MA) CHO
Patent Number(s):
US 5561043
Contract Number:
FG02-93ER61656
Research Org:
Boston University
Country of Publication:
United States
Language:
English
Subject:
self-assembling; multimeric; nucleic; acid; constructs; directed; compositions; containing; forms; acids; comprise; single-stranded; attached; via; biotin; streptavidin; bound; functional; utilized; vivo; treat; identify; diseased; tissue; cells; repeated; administrations; produce; rapid; specific; amplification; treatment; purposes; toxins; radioisotopes; genes; enzymes; diagnostically; labeled; targets; vitro; nanotechnology; create; polymeric; aggregates; membranes; defined; porosity; microcircuits; products; nucleic acid; nucleic acids; compositions containing; single-stranded nucleic; multimeric nucleic; specific target; identify specific; attached via; acid constructs; self-assembling multimeric; compositions contain; compositions produce; comprise single-stranded; multimeric forms; diseased tissue; via biotin; stranded nucleic; acids attached; acids comprise; containing multimeric; /435/999/