Nucleosides with 5'-O-photolabile protecting groups

Foote, Robert S; Sachleben, Richard A

Title: Nucleosides with 5'-O-photolabile protecting groups

Full Record
Other Related Research

Abstract

Nucleosides with photolabile protecting groups on the 5'-hydroxyl. These nucleosides are useful in the sythesis of nucleic acids on solid-state arrays.

Inventors:

Foote, Robert S ^[1]; Sachleben, Richard A ^[2]

105 Elliot Cir., Oak Ridge, TN 37830
1105 Hickory Trail, Knoxville, TN 37932

Issue Date:: 1996-09-17

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 870602

Patent Number(s):: 5556961

Application Number:: 08/328,079

Assignee:: Foote, Robert S. (105 Elliot Cir., Oak Ridge, TN 37830);Sachleben, Richard A. (1105 Hickory Trail, Knoxville, TN 37932)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Show more

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00315 - Microtiter plates

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/55 - Synthetic design, e.g. reducing the use of auxiliary or protecting groups

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00722 - Nucleotides

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C07H21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00612 - the surface being inorganic

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C07H19/06 - Pyrimidine radicals

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00637 - by coating it with another layer

C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
C40B60/14 - for creating libraries

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/0059 - Sequential processes

C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
C40B40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00659 - Two-dimensional arrays
B01J2219/00608 - DNA chips
B01J2219/00585 - Parallel processes
B01J2219/00529 - DNA chips
B01J2219/00527 - Sheets
B01J2219/00711 - Light-directed synthesis

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C07H19/16 - Purine radicals

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J19/0046 - {Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides
B01J2219/00596 - Solid-phase processes
B01J2219/00432 - Photolithographic masks

Show less

DOE Contract Number:: 41B-99732

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: nucleosides; -o-photolabile; protecting; photolabile; -hydroxyl; useful; sythesis; nucleic; acids; solid-state; arrays; nucleic acid; nucleic acids; /999/

Citation Formats


                    Foote, Robert S, and Sachleben, Richard A. Nucleosides with 5'-O-photolabile protecting groups.  United States: N. p., 1996. 
        Web.

Copy to clipboard


                    Foote, Robert S, & Sachleben, Richard A. Nucleosides with 5'-O-photolabile protecting groups.  United States.

Copy to clipboard


                    Foote, Robert S, and Sachleben, Richard A. Tue .  
        "Nucleosides with 5'-O-photolabile protecting groups".  United States.  https://www.osti.gov/servlets/purl/870602.

Copy to clipboard


                    
@article{osti_870602,

  title        = {Nucleosides with 5'-O-photolabile protecting groups},

  author       = {Foote, Robert S and Sachleben, Richard A},

  abstractNote = {Nucleosides with photolabile protecting groups on the 5'-hydroxyl. These nucleosides are useful in the sythesis of nucleic acids on solid-state arrays.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1996},

  month        = {9}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE Patents and OSTI.GOV collections:

5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group

Patent Pirrung, Michael C [Houston, TX]; Shuey, Steven W [Durham, NC]; Bradley, Jean-Claude [Durham, NC]

The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5' to 3' nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5' end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
Full Text Available
Combined group ECC protection and subgroup parity protection

Patent Gara, Alan; Chen, Dong; Heidelberger, Philip; ...

A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit widemore » « less
Full Text Available
Combined group ECC protection and subgroup parity protection

Patent Gara, Alan; Cheng, Dong; Heidelberger, Philip; ...

A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit widemore » « less
Full Text Available
Combined group ECC protection and subgroup parity protection

Patent Gara, Alan G.; Chen, Dong; Heidelberger, Philip; ...

A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit widemore » « less
Full Text Available
Alkylated photoremovable protecting groups and uses thereof

Patent Winter, Arthur Henry

The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.
Full Text Available

Similar Records