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Title: Noise suppressing capillary separation system

Abstract

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

Inventors:
 [1];  [2]
  1. Ames, IA
  2. Norwich, NY
Issue Date:
Research Org.:
Ames Lab., Ames, IA (United States); Iowa State Univ., Ames, IA (United States)
OSTI Identifier:
870536
Patent Number(s):
5540825
Application Number:
08/406,714
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-82
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
noise; suppressing; capillary; separation; noise-suppressing; detecting; real-time; presence; concentration; analyte; sample; provided; contains; means; moved; coherent; light; source; generates; beam; split; reference; irradiate; detector; transmits; laser; wavelength; effective; absorbed; chromophore; improve; performance; accuracy; signal; averaging; multiple; scans; reference beam; light source; laser beam; coherent light; sample beam; separation means; wavelength effective; beam light; capillary separation; improve performance; suppressing capillary; /204/73/356/

Citation Formats

Yeung, Edward S, and Xue, Yongjun. Noise suppressing capillary separation system. United States: N. p., 1996. Web.
Yeung, Edward S, & Xue, Yongjun. Noise suppressing capillary separation system. United States.
Yeung, Edward S, and Xue, Yongjun. Mon . "Noise suppressing capillary separation system". United States. https://www.osti.gov/servlets/purl/870536.
@article{osti_870536,
title = {Noise suppressing capillary separation system},
author = {Yeung, Edward S and Xue, Yongjun},
abstractNote = {A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}

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Works referenced in this record:

Reaching the shot Noise Limit for $10
journal, January 1991


Capillary Electrophoresis
journal, February 1989


Indirect Detection Methods for Capillary Separations
journal, March 1991


Double-beam laser absorption spectroscopy: shot noise-limited performance at baseband with a novel electronic noise canceler
conference, July 1991

  • Haller, Kurt L.; Hobbs, Philip C. D.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings
  • https://doi.org/10.1117/12.44253

Detection method for ion chromatography based on double-beam laser-excited indirect fluorometry
journal, October 1985


Axial-beam absorbance detection for capillary electrophoresis
journal, January 1991


Determination of amino acids by capillary zone electrophoresis based on semiconductor laser fluorescence detection
journal, April 1992


Shot noise limited optical measurements at baseband with noisy lasers (proceedings Only)
conference, March 1991


Diode laser-based indirect absorbance detector for capillary electrophoresis
journal, April 1993