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Title: Noise suppressing capillary separation system

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.
 [1];  [2]
  1. (Ames, IA)
  2. (Norwich, NY)
Issue Date:
OSTI Identifier:
Iowa State University Research Foundation, Inc. (Ames, IA) AMES
Patent Number(s):
US 5540825
Application Number:
Contract Number:
Research Org:
Ames Laboratory (AMES), Ames, IA; Iowa State University, Ames, IA (US)
Country of Publication:
United States
noise; suppressing; capillary; separation; noise-suppressing; detecting; real-time; presence; concentration; analyte; sample; provided; contains; means; moved; coherent; light; source; generates; beam; split; reference; irradiate; detector; transmits; laser; wavelength; effective; absorbed; chromophore; improve; performance; accuracy; signal; averaging; multiple; scans; reference beam; light source; laser beam; coherent light; sample beam; separation means; wavelength effective; beam light; capillary separation; improve performance; suppressing capillary; /204/73/356/