Polypeptide having an amino acid replaced with N-benzylglycine
Abstract
The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.
- Inventors:
-
- Livermore, CA
- Los Angeles, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 870479
- Patent Number(s):
- 5527882
- Assignee:
- Regents of University of California (Alameda, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- polypeptide; amino; acid; replaced; n-benzylglycine; relates; polypeptides; useful; biological; activity; mammal; comprise; related; bradykinin; residues; specific; acids; chain; achiral; analogues; potent; agonist; antagonist; pharmacological; properties; depending; structure; preferred; -bradykinin; amino acid; amino acids; acid residues; acid residue; /530/
Citation Formats
Mitchell, Alexander R, and Young, Janis D. Polypeptide having an amino acid replaced with N-benzylglycine. United States: N. p., 1996.
Web.
Mitchell, Alexander R, & Young, Janis D. Polypeptide having an amino acid replaced with N-benzylglycine. United States.
Mitchell, Alexander R, and Young, Janis D. Mon .
"Polypeptide having an amino acid replaced with N-benzylglycine". United States. https://www.osti.gov/servlets/purl/870479.
@article{osti_870479,
title = {Polypeptide having an amino acid replaced with N-benzylglycine},
author = {Mitchell, Alexander R and Young, Janis D},
abstractNote = {The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1996},
month = {Mon Jan 01 00:00:00 EST 1996}
}
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