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Title: Polypeptide having an amino acid replaced with N-benzylglycine

The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine.sup.7)-bradykinin.
Inventors:
 [1];  [2]
  1. (Livermore, CA)
  2. (Los Angeles, CA)
Issue Date:
OSTI Identifier:
870479
Assignee:
Regents of University of California (Alameda, CA) LLNL
Patent Number(s):
US 5527882
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Country of Publication:
United States
Language:
English
Subject:
polypeptide; amino; acid; replaced; n-benzylglycine; relates; polypeptides; useful; biological; activity; mammal; comprise; related; bradykinin; residues; specific; acids; chain; achiral; analogues; potent; agonist; antagonist; pharmacological; properties; depending; structure; preferred; -bradykinin; amino acid; amino acids; acid residues; acid residue; /530/

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