Electrorheological crystallization of proteins and other molecules
Abstract
An electrorheological crystalline mass of a molecule is formed by dispersing the molecule in a dispersion fluid and subjecting the molecule dispersion to a uniform electrical field for a period of time during which time an electrorheological crystalline mass is formed. Molecules that may be used to form an electrorheological crystalline mass include any organic or inorganic molecule which has a permanent dipole and/or which is capable of becoming an induced dipole in the presence of an electric field. The molecules used to form the electrorheological crystalline mass are preferably macromolecules, such as biomolecules, such as proteins, nucleic acids, carbohydrates, lipoproteins and viruses. Molecules are crystallized by a method in which an electric field is maintained for a period of time after the electrorheological crystalline mass has formed during which time at least some of the molecules making up the electrorheological crystalline mass form a crystal lattice. The three dimensional structure of a molecule is determined by a method in which an electrorheological crystalline mass of the molecule is formed, an x-ray diffraction pattern of the electrorheological crystalline mass is obtained and the three dimensional structure of the molecule is calculated from the x-ray diffraction pattern.
- Inventors:
-
- Lafayette, CA
- Dublin, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 870450
- Patent Number(s):
- 5525198
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C10 - PETROLEUM, GAS OR COKE INDUSTRIES C10M - LUBRICATING COMPOSITIONS
C - CHEMISTRY C30 - CRYSTAL GROWTH C30B - SINGLE-CRYSTAL-GROWTH
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- electrorheological; crystallization; proteins; molecules; crystalline; mass; molecule; formed; dispersing; dispersion; fluid; subjecting; uniform; electrical; field; period; time; form; organic; inorganic; permanent; dipole; capable; becoming; induced; presence; electric; preferably; macromolecules; biomolecules; nucleic; acids; carbohydrates; lipoproteins; viruses; crystallized; method; maintained; crystal; lattice; dimensional; structure; determined; x-ray; diffraction; pattern; obtained; calculated; electrical field; x-ray diffraction; electric field; nucleic acid; nucleic acids; crystal lattice; diffraction pattern; organic molecule; dimensional structure; uniform electrical; uniform electric; form electrical; /204/205/378/435/
Citation Formats
Craig, George D, and Rupp, Bernhard. Electrorheological crystallization of proteins and other molecules. United States: N. p., 1996.
Web.
Craig, George D, & Rupp, Bernhard. Electrorheological crystallization of proteins and other molecules. United States.
Craig, George D, and Rupp, Bernhard. Mon .
"Electrorheological crystallization of proteins and other molecules". United States. https://www.osti.gov/servlets/purl/870450.
@article{osti_870450,
title = {Electrorheological crystallization of proteins and other molecules},
author = {Craig, George D and Rupp, Bernhard},
abstractNote = {An electrorheological crystalline mass of a molecule is formed by dispersing the molecule in a dispersion fluid and subjecting the molecule dispersion to a uniform electrical field for a period of time during which time an electrorheological crystalline mass is formed. Molecules that may be used to form an electrorheological crystalline mass include any organic or inorganic molecule which has a permanent dipole and/or which is capable of becoming an induced dipole in the presence of an electric field. The molecules used to form the electrorheological crystalline mass are preferably macromolecules, such as biomolecules, such as proteins, nucleic acids, carbohydrates, lipoproteins and viruses. Molecules are crystallized by a method in which an electric field is maintained for a period of time after the electrorheological crystalline mass has formed during which time at least some of the molecules making up the electrorheological crystalline mass form a crystal lattice. The three dimensional structure of a molecule is determined by a method in which an electrorheological crystalline mass of the molecule is formed, an x-ray diffraction pattern of the electrorheological crystalline mass is obtained and the three dimensional structure of the molecule is calculated from the x-ray diffraction pattern.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}
Works referenced in this record:
Electrorheological Fluids
journal, October 1993
- Halsey, Thomas C.; Martin, James E.
- Scientific American, Vol. 269, Issue 4
Electro-rheology
journal, December 1988
- Block, H.; Kelly, J. P.
- Journal of Physics D: Applied Physics, Vol. 21, Issue 12