Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa
Abstract
A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.
- Inventors:
-
- Los Angeles, CA
- Agoura Hills, CA
- Wahnemuhle, DE
- Shreveport, LA
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- OSTI Identifier:
- 870385
- Patent Number(s):
- 5510522
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- FC03-87ER60615
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- synthesis; n-formyl-3; 4-di-t-butoxycarbonyloxy-6-; trimethylstannyl; -l-phenylalanine; ethyl; ester; regioselective; radiofluorodestannylation; 6-; 18; fluoro-1-dopa; process; forming; 6-fluoro; derivative; compounds; l-dopa; family; comprising; steps; protecting; attached; benzene; compound; followed; serially; reacting; protected; iodine; silver; trifluoroacetic; acid; bb; dit-butyldicarbonate; hexamethyltin; fluoro; hydrobromic; raising; ph; ltoreq; acetic acid; regioselective radiofluorodestannylation; ethyl ester; -l-phenylalanine ethyl; /999/
Citation Formats
Satyamurthy, Nagichettiar, Barrio, Jorge R, Bishop, Allyson J, Namavari, Mohammad, and Bida, Gerald T. Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa. United States: N. p., 1996.
Web.
Satyamurthy, Nagichettiar, Barrio, Jorge R, Bishop, Allyson J, Namavari, Mohammad, & Bida, Gerald T. Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa. United States.
Satyamurthy, Nagichettiar, Barrio, Jorge R, Bishop, Allyson J, Namavari, Mohammad, and Bida, Gerald T. Mon .
"Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa". United States. https://www.osti.gov/servlets/purl/870385.
@article{osti_870385,
title = {Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa},
author = {Satyamurthy, Nagichettiar and Barrio, Jorge R and Bishop, Allyson J and Namavari, Mohammad and Bida, Gerald T},
abstractNote = {A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}
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