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Title: Multiplexed fluorescence detector system for capillary electrophoresis

A fluorescence detection system for capillary electrophoresis is provided wherein the detection system can simultaneously excite fluorescence and substantially simultaneously monitor separations in multiple capillaries. This multiplexing approach involves laser irradiation of a sample in a plurality of capillaries through optical fibers that are coupled individually with the capillaries. The array is imaged orthogonally through a microscope onto a charge-coupled device camera for signal analysis.
Inventors:
 [1];  [2]
  1. (Ames, IA)
  2. (Nevada, IA)
Issue Date:
OSTI Identifier:
870334
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA) AMES
Patent Number(s):
US 5498324
Application Number:
08/223,864
Contract Number:
W-7405-ENG-82
Research Org:
Ames Laboratory (AMES), Ames, IA; Iowa State University, Ames, IA (US)
Country of Publication:
United States
Language:
English
Subject:
multiplexed; fluorescence; detector; capillary; electrophoresis; detection; provided; simultaneously; excite; substantially; monitor; separations; multiple; capillaries; multiplexing; approach; involves; laser; irradiation; sample; plurality; optical; fibers; coupled; individually; array; imaged; orthogonally; microscope; charge-coupled; device; camera; signal; analysis; fluorescence detection; charge-coupled device; multiple capillaries; laser irradiation; coupled device; substantially simultaneously; capillary electrophoresis; optical fibers; optical fiber; signal analysis; approach involves; fluorescence detector; simultaneously monitor; simultaneously excite; multiplexed fluorescence; device camera; excite fluorescence; substantially simultaneous; /204/356/

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