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Title: Automated two-dimensional interface for capillary gas chromatography

A multidimensional gas chromatograph (GC) system having wide bore capillary and narrow bore capillary GC columns in series and having a novel system interface. Heart cuts from a high flow rate sample, separated by a wide bore GC column, are collected and directed to a narrow bore GC column with carrier gas injected at a lower flow compatible with a mass spectrometer. A bimodal six-way valve is connected with the wide bore GC column outlet and a bimodal four-way valve is connected with the narrow bore GC column inlet. A trapping and retaining circuit with a cold trap is connected with the six-way valve and a transfer circuit interconnects the two valves. The six-way valve is manipulated between first and second mode positions to collect analyte, and the four-way valve is manipulated between third and fourth mode positions to allow carrier gas to sweep analyte from a deactivated cold trap, through the transfer circuit, and then to the narrow bore GC capillary column for separation and subsequent analysis by a mass spectrometer. Rotary valves have substantially the same bore width as their associated columns to minimize flow irregularities and resulting sample peak deterioration. The rotary valves are heated separately frommore » the GC columns to avoid temperature lag and resulting sample deterioration.« less
Inventors:
 [1];  [1]
  1. (Albuquerque, NM)
Issue Date:
OSTI Identifier:
870301
Assignee:
Lovelace Biomedical & Environmental Research Institute, Inc. (Albuquerque, NM) SNL
Patent Number(s):
US 5492555
Application Number:
08/257,388
Contract Number:
AC04-76EV01013
Research Org:
LOVELACE BIOMED & ENV RES INST
Country of Publication:
United States
Language:
English
Subject:
automated; two-dimensional; interface; capillary; gas; chromatography; multidimensional; chromatograph; gc; wide; bore; narrow; columns; series; novel; heart; cuts; flow; rate; sample; separated; column; collected; directed; carrier; injected; compatible; mass; spectrometer; bimodal; six-way; valve; connected; outlet; four-way; inlet; trapping; retaining; circuit; cold; trap; transfer; interconnects; valves; manipulated; mode; positions; collect; analyte; third; fourth; allow; sweep; deactivated; separation; subsequent; analysis; rotary; substantially; width; associated; minimize; irregularities; resulting; peak; deterioration; heated; separately; avoid; temperature; lag; rotary valves; narrow bore; subsequent analysis; capillary column; gas chromatography; cold trap; mass spectrometer; carrier gas; flow rate; gas chromatograph; transfer circuit; gas injected; capillary gas; bore capillary; rotary valve; capillary gc; /95/73/96/