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Title: Biomarkers of cell senescence

Abstract

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in in vitro cell cultures or in vivo.

Inventors:
 [1];  [2];  [3]
  1. Simli U.P., IN
  2. Berkeley, CA
  3. Newton, MA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
870293
Patent Number(s):
5491069
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
biomarkers; cell; senescence; provides; biomarker; vivo; vitro; assessment; method; beta; -galactosidase; activity; utilized; means; assessed; cultures; cell senescence; cell culture; cell cultures; vitro assessment; vitro cell; -galactosidase activity; /435/436/

Citation Formats

Dirmi, Goberdhan P, Campisi, Judith, and Peacocke, Monica. Biomarkers of cell senescence. United States: N. p., 1996. Web.
Dirmi, Goberdhan P, Campisi, Judith, & Peacocke, Monica. Biomarkers of cell senescence. United States.
Dirmi, Goberdhan P, Campisi, Judith, and Peacocke, Monica. Mon . "Biomarkers of cell senescence". United States. https://www.osti.gov/servlets/purl/870293.
@article{osti_870293,
title = {Biomarkers of cell senescence},
author = {Dirmi, Goberdhan P and Campisi, Judith and Peacocke, Monica},
abstractNote = {The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in in vitro cell cultures or in vivo.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}

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Works referenced in this record:

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