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Title: Method for protection against genotoxic mutagenesis

Abstract

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.

Inventors:
 [1]
  1. Naperville, IL
Issue Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL
OSTI Identifier:
870278
Patent Number(s):
5488042
Assignee:
Arch Development Corporation (Chicago, IL)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; damage; irradiated; cells; reduction; mutations; hypoxanthine-guanine; phosphoribosyl; transferase; locus; accomplished; administering; effective; dose; compound; protected; sulfhydryl; metabolize; vivo; produce; free; disulfides; genotoxic mutagenesis; /514/

Citation Formats

Grdina, David J. Method for protection against genotoxic mutagenesis. United States: N. p., 1996. Web.
Grdina, David J. Method for protection against genotoxic mutagenesis. United States.
Grdina, David J. Mon . "Method for protection against genotoxic mutagenesis". United States. https://www.osti.gov/servlets/purl/870278.
@article{osti_870278,
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, David J},
abstractNote = {A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}

Patent:

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