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Title: Method for protection against genotoxic mutagenesis

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.
Inventors:
 [1]
  1. (Naperville, IL)
Issue Date:
OSTI Identifier:
870278
Assignee:
Arch Development Corporation (Chicago, IL) ANL
Patent Number(s):
US 5488042
Contract Number:
W-31109-ENG-38
Research Org:
Argonne National Laboratory (ANL), Argonne, IL
Country of Publication:
United States
Language:
English
Subject:
method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; damage; irradiated; cells; reduction; mutations; hypoxanthine-guanine; phosphoribosyl; transferase; locus; accomplished; administering; effective; dose; compound; protected; sulfhydryl; metabolize; vivo; produce; free; disulfides; genotoxic mutagenesis; /514/

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