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Title: Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

Abstract

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Patchogue, NY
  2. Bellport, NY
  3. Westhampton, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
870246
Patent Number(s):
5482865
Application Number:
08/258,053
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Classifications (CPCs):
G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; preparing; oxygen-15; labeled; water; 15; injectable; form; positron; emission; tomography; handling; processing; preferably; produced; irradiating; flowing; gas; target; nitrogen; hydrogen; collector; receiving; directing; containing; impurities; mainly; ammonia; nh; sterile; trap; ammonium; device; displacing; cation; resin; removes; combining; saline; solution; produces; delivering; syringe; injection; patient; disclosed; neither; requires; isotopic; exchange; reaction; nor; application; temperature; saline solution; gas containing; emission tomography; positron emission; water containing; processing apparatus; flowing gas; exchange reaction; oxygen-15 labeled; gas target; injectable form; preparing oxygen-15; labeled water; /436/250/376/422/

Citation Formats

Ferrieri, Richard A, Schlyer, David J, and Alexoff, David. Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography. United States: N. p., 1996. Web.
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Ferrieri, Richard A, Schlyer, David J, & Alexoff, David. Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography. United States.
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Ferrieri, Richard A, Schlyer, David J, and Alexoff, David. Tue . "Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography". United States. https://www.osti.gov/servlets/purl/870246.
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@article{osti_870246,
title = {Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography},
author = {Ferrieri, Richard A and Schlyer, David J and Alexoff, David},
abstractNote = {A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 09 00:00:00 EST 1996},
month = {Tue Jan 09 00:00:00 EST 1996}
}
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Works referenced in this record:

Low-carrier production of [15O]oxygen, water and carbon monoxide
journal, January 1990

  • Berridge, M. S.; Terris, A. H.; Cassidy, E. H.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 12
  • https://doi.org/10.1016/0883-2889(90)90202-R

Current methodology for oxygen-15 production for clinical use
journal, January 1987

A remote system for the routine production of oxygen-15 radiopharmaceuticals
journal, November 1985

Direct synthesis of oxygen-15 labelled water at high specific activities
journal, October 1978

Direct simultaneous production of [15O]water and [13N]ammonia or [18F]fluoride ion by 26 MeV proton irradiation of a double chamber water target
journal, January 1990

  • Mulholland, G. Keith; Kilbourn, Michael R.; Moskwa, James J.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 12
  • https://doi.org/10.1016/0883-2889(90)90206-V
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