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Title: Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.
Inventors:
 [1];  [2];  [3]
  1. (Patchogue, NY)
  2. (Bellport, NY)
  3. (Westhampton, NY)
Issue Date:
OSTI Identifier:
870246
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5482865
Application Number:
08/258,053
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
apparatus; method; preparing; oxygen-15; labeled; water; 15; injectable; form; positron; emission; tomography; handling; processing; preferably; produced; irradiating; flowing; gas; target; nitrogen; hydrogen; collector; receiving; directing; containing; impurities; mainly; ammonia; nh; sterile; trap; ammonium; device; displacing; cation; resin; removes; combining; saline; solution; produces; delivering; syringe; injection; patient; disclosed; neither; requires; isotopic; exchange; reaction; nor; application; temperature; saline solution; gas containing; emission tomography; positron emission; water containing; processing apparatus; flowing gas; exchange reaction; oxygen-15 labeled; gas target; injectable form; preparing oxygen-15; labeled water; /436/250/376/422/

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