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Title: Detection of amplified or deleted chromosomal regions

Abstract

The present invention relates to in situ hybridization methods for the identification of new chromosomal abnormalities associated with various diseases. In particular, it provides probes which are specific to a region of amplification in chromosome 20.

Inventors:
 [1];  [2];  [1]
  1. San Francisco, CA
  2. Walnut Creek, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
870192
Patent Number(s):
5472842
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
detection; amplified; deleted; chromosomal; regions; relates; situ; hybridization; methods; identification; abnormalities; associated; various; diseases; particular; provides; probes; specific; region; amplification; chromosome; 20; various diseases; chromosomal abnormalities; hybridization methods; situ hybridization; provides probes; abnormalities associated; chromosomal region; /435/999/

Citation Formats

Stokke, Trond, Pinkel, Daniel, and Gray, Joe W. Detection of amplified or deleted chromosomal regions. United States: N. p., 1995. Web.
Stokke, Trond, Pinkel, Daniel, & Gray, Joe W. Detection of amplified or deleted chromosomal regions. United States.
Stokke, Trond, Pinkel, Daniel, and Gray, Joe W. Sun . "Detection of amplified or deleted chromosomal regions". United States. https://www.osti.gov/servlets/purl/870192.
@article{osti_870192,
title = {Detection of amplified or deleted chromosomal regions},
author = {Stokke, Trond and Pinkel, Daniel and Gray, Joe W},
abstractNote = {The present invention relates to in situ hybridization methods for the identification of new chromosomal abnormalities associated with various diseases. In particular, it provides probes which are specific to a region of amplification in chromosome 20.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {1}
}

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Works referenced in this record:

Complete characterization of a large marker chromosome by reverse and forward chromosome painting
journal, December 1992


Analytical strategies for the use of DNA probes
journal, February 1988


Translocations between two specific human chromosomes detected by three-color “chromosome painting”
journal, January 1993


Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe
journal, February 1993


Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.
journal, December 1988


Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.
journal, March 1994


Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
journal, October 1992


High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones
journal, January 1990


In situ hybridisation with fluoresceinated DNA
journal, January 1991


Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma
journal, May 1991


ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.
journal, June 1992