Apparatus and method for polymer synthesis using arrays
Abstract
A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24) , and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the reaction wells (26) and selected nozzles (22) for deposition of the liquid reagent (24) into selected reaction wells (26). A sliding seal (30) is positioned between the head assembly (21) and the base assembly (25) to form a common chamber (31) enclosing both the reaction well (26) and the nozzles (22) therein. A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31) , downstream from the nozzles (22) , sweeps the common chamber ( 31 ) of toxic fumes emitted by the reagents. Each reaction well (26) includes an orifice (74) extending into the well (26) which is of a size and dimension to form a capillary liquid seal to retain the reagent solution (76) in the well (26) for polymer chain growth therein. A pressure regulating device (82) is provided for controllingmore »
- Inventors:
-
- San Francisco, CA
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 870190
- Patent Number(s):
- 5472672
- Assignee:
- Board of Trustees of Leland Stanford Junior University (Stanford, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
- DOE Contract Number:
- DOE LBL 4437-10
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- apparatus; method; polymer; synthesis; arrays; 20; building; chain; including; head; assembly; 21; array; nozzles; 22; nozzle; coupled; reservoir; 23; liquid; reagent; 24; base; 25; reaction; 26; transport; mechanism; 27; aligns; selected; deposition; sliding; seal; 30; positioned; form; common; chamber; 31; enclosing; therein; gas; inlet; 70; upstream; outlet; 71; downstream; sweeps; toxic; fumes; emitted; reagents; orifice; 74; extending; size; dimension; capillary; retain; solution; 76; growth; pressure; regulating; device; 82; provided; controlling; differential; exerted; exit; 80; exceeding; predetermined; amount; expelled; included; selected reaction; transport mechanism; liquid seal; polymer synthesis; pressure regulating; liquid reagent; regulating device; synthesis apparatus; head assembly; gas outlet; gas inlet; pressure differential; gas pressure; reagent solution; common chamber; polymer chain; predetermined amount; pressure exerted; chain growth; capillary liquid; nozzle coupled; chain including; growth therein; /422/
Citation Formats
Brennan, Thomas M. Apparatus and method for polymer synthesis using arrays. United States: N. p., 1995.
Web.
Brennan, Thomas M. Apparatus and method for polymer synthesis using arrays. United States.
Brennan, Thomas M. Sun .
"Apparatus and method for polymer synthesis using arrays". United States. https://www.osti.gov/servlets/purl/870190.
@article{osti_870190,
title = {Apparatus and method for polymer synthesis using arrays},
author = {Brennan, Thomas M},
abstractNote = {A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24) , and a base assembly (25) having an array of reaction wells (26). A transport mechanism (27) aligns the reaction wells (26) and selected nozzles (22) for deposition of the liquid reagent (24) into selected reaction wells (26). A sliding seal (30) is positioned between the head assembly (21) and the base assembly (25) to form a common chamber (31) enclosing both the reaction well (26) and the nozzles (22) therein. A gas inlet (70) into the common chamber (31), upstream from the nozzles (22), and a gas outlet (71) out of the common chamber (31) , downstream from the nozzles (22) , sweeps the common chamber ( 31 ) of toxic fumes emitted by the reagents. Each reaction well (26) includes an orifice (74) extending into the well (26) which is of a size and dimension to form a capillary liquid seal to retain the reagent solution (76) in the well (26) for polymer chain growth therein. A pressure regulating device (82) is provided for controlling a pressure differential, between a first gas pressure exerted on the reaction well (26) and a second gas pressure exerted on an exit (80) of the orifice, such that upon the pressure differential exceeding a predetermined amount, the reagent solution (76) is expelled from the well (26) through the orifice (74). A method of synthesis of a polymer chain in a synthesis apparatus (20) is also included.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {1}
}
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