Global to push GA events into
skip to main content

Title: Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
 [1];  [2]
  1. (Hampton Bays, NY)
  2. (Southold, NY)
Issue Date:
OSTI Identifier:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5455022
Application Number:
Contract Number:
Research Org:
Country of Publication:
United States
halogenated; sulfidohydroboranes; nuclear; medicine; boron; neutron; capture; therapy; method; performing; treatment; tumors; disclosed; administering; patient; iodinated; sulfidohydroborane; boron-10-containing; compound; site; tumor; localized; visualizing; increased; concentration; iodine; labelled; targeted; irradiated; beam; neutrons; energy; distribution; effective; destruction; occurs; due; particle; irradiation; tissue; secondary; incident; captured; boron-10; nuclei; especially; suitable; preferred; embodiment; formula; na; 12; 11; ssb; pharmaceutically; acceptable; salt; administered; cancer; occurs due; containing compound; distribution effective; nuclear medicine; preferred embodiment; neutron capture; energy distribution; boron neutron; capture therapy; especially suitable; pharmaceutically acceptable; tissue secondary; tumor occurs; boron-10-containing compound; boron-10 nuclei; cancer patient; performing boron; acceptable salt; particle irradiation; incident neutrons; targeted tumor; halogenated sulfidohydroboranes; labelled compound; iodinated sulfidohydroboranes; iodinated sulfidohydroborane; iodine labelled; increased concentration; formula na; /424/423/