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Title: Method for immunodiagnostic detection of dioxins at low concentrations

Abstract

A method is described for the use of monoclonal antibodies in a sensitive immunoassay for halogenated dioxins and dibenzofurans in industrial samples which contain impurities. Appropriate sample preparation and selective enzyme amplification of the immunoassay sensitivity permits detection of dioxin contaminants in industrial or environmental samples at concentrations in the range of a few parts per trillion.

Inventors:
 [1];  [2];  [2];  [3];  [4]
  1. Danville, CA
  2. Livermore, CA
  3. Hochheim am Main, DE
  4. Eppstein/Ts., DE
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
869959
Patent Number(s):
5429925
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; immunodiagnostic; detection; dioxins; concentrations; described; monoclonal; antibodies; sensitive; immunoassay; halogenated; dibenzofurans; industrial; samples; contain; impurities; appropriate; sample; preparation; selective; enzyme; amplification; sensitivity; permits; dioxin; contaminants; environmental; range; trillion; permits detection; environmental sample; sample preparation; monoclonal antibodies; environmental samples; sensitive immunoassay; /435/436/

Citation Formats

Vanderlaan, Martin, Stanker, Larry H, Watkins, Bruce E, Petrovic, Peter, and Gorbach, Siegbert. Method for immunodiagnostic detection of dioxins at low concentrations. United States: N. p., 1995. Web.
Vanderlaan, Martin, Stanker, Larry H, Watkins, Bruce E, Petrovic, Peter, & Gorbach, Siegbert. Method for immunodiagnostic detection of dioxins at low concentrations. United States.
Vanderlaan, Martin, Stanker, Larry H, Watkins, Bruce E, Petrovic, Peter, and Gorbach, Siegbert. Sun . "Method for immunodiagnostic detection of dioxins at low concentrations". United States. https://www.osti.gov/servlets/purl/869959.
@article{osti_869959,
title = {Method for immunodiagnostic detection of dioxins at low concentrations},
author = {Vanderlaan, Martin and Stanker, Larry H and Watkins, Bruce E and Petrovic, Peter and Gorbach, Siegbert},
abstractNote = {A method is described for the use of monoclonal antibodies in a sensitive immunoassay for halogenated dioxins and dibenzofurans in industrial samples which contain impurities. Appropriate sample preparation and selective enzyme amplification of the immunoassay sensitivity permits detection of dioxin contaminants in industrial or environmental samples at concentrations in the range of a few parts per trillion.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {1}
}

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Works referenced in this record:

Monoclonal antibodies to chlorinated dibenzo-p-dioxins
journal, February 1986


Improvement and application of an immunoassay for screening environmental samples for dioxin contamination
journal, November 1988


Analysis of polychlorinated dioxins and furans
journal, March 1984


The use of avidin-biotin interaction in immunoenzymatic techniques.
journal, August 1979


ES&T Critical Review: Environmental monitoring by immunoassay
journal, March 1988