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Title: Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.
Inventors:
 [1];  [2];  [3]
  1. (Patchogue, NY)
  2. (Bellport, NY)
  3. (Wading River, NY)
Issue Date:
OSTI Identifier:
869932
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5425063
Application Number:
08/042,741
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
method; selective; recovery; pet-usable; quantities; 18; fluoride; 13; nitrate; nitrite; single; irradiation; low-enriched; water; process; simultaneously; producing; nh; radiotracer; synthesis; disclosed; exposing; 20; -30; target; proton; sequentially; isolating; reducing; products; conveyed; laboratory; applications; employs; anion; exchange; resin; isolation; isotopes; sequential; elution; fractions; apparatus; anion exchange; exchange resin; process employs; selective recovery; sequential elution; pet-usable quantities; proton irradiation; radiotracer synthesis; usable quantities; /376/

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