Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water
Abstract
A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.
- Inventors:
-
- Patchogue, NY
- Bellport, NY
- Wading River, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 869932
- Patent Number(s):
- 5425063
- Application Number:
- 08/042,741
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; selective; recovery; pet-usable; quantities; 18; fluoride; 13; nitrate; nitrite; single; irradiation; low-enriched; water; process; simultaneously; producing; nh; radiotracer; synthesis; disclosed; exposing; 20; -30; target; proton; sequentially; isolating; reducing; products; conveyed; laboratory; applications; employs; anion; exchange; resin; isolation; isotopes; sequential; elution; fractions; apparatus; anion exchange; exchange resin; process employs; selective recovery; sequential elution; pet-usable quantities; proton irradiation; radiotracer synthesis; usable quantities; /376/
Citation Formats
Ferrieri, Richard A, Schlyer, David J, and Shea, Colleen. Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water. United States: N. p., 1995.
Web.
Ferrieri, Richard A, Schlyer, David J, & Shea, Colleen. Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water. United States.
Ferrieri, Richard A, Schlyer, David J, and Shea, Colleen. Tue .
"Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water". United States. https://www.osti.gov/servlets/purl/869932.
@article{osti_869932,
title = {Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water},
author = {Ferrieri, Richard A and Schlyer, David J and Shea, Colleen},
abstractNote = {A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {6}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a potential brain-scanning agent
journal, August 1982
- Irie, Toshiaki; Fukushi, Kiyoshi; Inoue, Osame
- The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 8
[18F]fluoride production with a circulating [18O]water target
journal, January 1987
- Iwata, Ren; Ido, Tatsuo; Brady, Frank
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 38, Issue 11
Recommendation for a practical production of [2-18F]fluoro-2-deoxy-D-glucose
journal, January 1987
- Coenen, H. H.; Pike, V. W.; Stöcklin, G.
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 38, Issue 8
« Les besoins d'emploi : contenu et problèmes posés par leur satisfaction » (à propos d'un article de R. Salais)
journal, January 1978
- Mériaux, Bernard
- Revue économique, Vol. 29, Issue 4
Production of radionuclides and labelled compounds from accelerators: Report of an international atomic energy agency consultants meeting
journal, January 1975
- Servian, Jorge L.
- The International Journal of Applied Radiation and Isotopes, Vol. 26, Issue 12, p. 763-770