Combined electrophoresis-electrospray interface and method

Smith, Richard D; Udseth, Harold R; Barinaga, Charles J

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Title: Combined electrophoresis-electrospray interface and method

Abstract

An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.

Inventors:

Smith, Richard D ^[1]; Udseth, Harold R ^[1]; Barinaga, Charles J ^[1]

Richland, WA

Issue Date:: 1995-01-01

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

OSTI Identifier:: 869923

Patent Number(s):: 5423964

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N27/44717 - {Arrangements for investigating the separated zones, e.g. localising zones}
G01N30/726 - {by electrical or glow discharge}

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/167 - {Capillaries and nozzles specially adapted therefor

Show less

DOE Contract Number:: AC06-76RL01830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: combined; electrophoresis-electrospray; interface; method; improvement; analyzing; molecular; constituents; composition; sample; comprises; improvements; electrospray; ionization; source; interfacing; mass; spectrometers; detection; devices; consists; establishing; unique; electrical; circuit; pattern; nozzle; configuration; metallic; coated; conical; shaped; capillary; outlet; coupled; sizing; obtain; maximum; sensitivity; molecular constituents; electrospray ionization; detection device; mass spectrometers; mass spectrometer; electrical circuit; circuit pattern; ionization source; shaped capillary; metallic coated; combined electrophoresis-electrospray; detection devices; composition sample; analyzing molecular; electrophoresis-electrospray interface; improvement consists; /204/250/

Citation Formats


                    Smith, Richard D, Udseth, Harold R, and Barinaga, Charles J. Combined electrophoresis-electrospray interface and method.  United States: N. p., 1995. 
        Web.

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                    Smith, Richard D, Udseth, Harold R, & Barinaga, Charles J. Combined electrophoresis-electrospray interface and method.  United States.

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                    Smith, Richard D, Udseth, Harold R, and Barinaga, Charles J. Sun .  
        "Combined electrophoresis-electrospray interface and method".  United States.  https://www.osti.gov/servlets/purl/869923.

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@article{osti_869923,

  title        = {Combined electrophoresis-electrospray interface and method},

  author       = {Smith, Richard D and Udseth, Harold R and Barinaga, Charles J},

  abstractNote = {An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1995},

  month        = {1}

}

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Works referenced in this record:

Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry
journal, September 1988

Smith, Richard D.; Barinaga, Charles J.; Udseth, Harold R.
Analytical Chemistry, Vol. 60, Issue 18
https://doi.org/10.1021/ac00169a022

Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry
journal, January 1993

Wahl, Jon H.; Goodlett, David R.; Udseth, Harold R.
Electrophoresis, Vol. 14, Issue 1
https://doi.org/10.1002/elps.1150140170

Capillary Electrophoresis/Mass Spectrometry
journal, July 1993

Smith, Richard D.; Wahl, Jon H.; Goodlett, David R.
Analytical Chemistry, Vol. 65, Issue 13
https://doi.org/10.1021/ac00061a717

Attomole level capillary electrophoresis-mass spectrometric protein analysis using 5 .mu.m i.d. capillaries
journal, December 1992

Wahl, Jon H.; Goodlett, David R.; Udseth, Harold R.
Analytical Chemistry, Vol. 64, Issue 24
https://doi.org/10.1021/ac00048a019

Instrumentation for high-performance capillary electrophoresis—mass spectrometry
journal, October 1991

Smith, Richard D.; Udseth, Harold R.; Barinaga, Charles J.
Journal of Chromatography A, Vol. 559, Issue 1-2
https://doi.org/10.1016/0021-9673(91)80070-W

Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 μm I.D. capillaries: Analyses of tryptic digests of cytochrome c
journal, January 1994

Wahl, Jon H.; Gale, David C.; Smith, Richard D.
Journal of Chromatography A, Vol. 659, Issue 1
https://doi.org/10.1016/0021-9673(94)85026-7

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Combined electrophoresis-electrospray interface and method

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A system and method for analyzing molecular constituents of a composition sample include: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5--100 kVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g.,{+-}2--8 kVDC) between the eluent at the capillarymore » « less

Similar Records

Title: Combined electrophoresis-electrospray interface and method

Abstract

Citation Formats

Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry journal, September 1988

Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry journal, January 1993

Capillary Electrophoresis/Mass Spectrometry journal, July 1993

Attomole level capillary electrophoresis-mass spectrometric protein analysis using 5 .mu.m i.d. capillaries journal, December 1992

Instrumentation for high-performance capillary electrophoresis—mass spectrometry journal, October 1991

Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 μm I.D. capillaries: Analyses of tryptic digests of cytochrome c journal, January 1994

Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry
journal, September 1988

Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry
journal, January 1993

Capillary Electrophoresis/Mass Spectrometry
journal, July 1993

Attomole level capillary electrophoresis-mass spectrometric protein analysis using 5 .mu.m i.d. capillaries
journal, December 1992

Instrumentation for high-performance capillary electrophoresis—mass spectrometry
journal, October 1991

Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 μm I.D. capillaries: Analyses of tryptic digests of cytochrome c
journal, January 1994