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Title: DNA complexes with dyes designed for energy transfer as fluorescent markers

Heteromultimeric fluorophores are provided for binding to DNA, which allow for the detection of DNA in electrical separations and preparation of probes having high-fluorescent efficiencies and large Stokes shifts. In addition, by appropriate choice of fluorescent molecules, one can use a single narrow wavelength band excitation light source, while obtaining fluorescent emissions having sufficient separation to be readily discriminated.
Inventors:
 [1];  [2]
  1. (Orinda, CA)
  2. (Albany, CA)
Issue Date:
OSTI Identifier:
869805
Assignee:
Regents of University of California (Oakland, CA) OAK
Patent Number(s):
US 5401847
Contract Number:
FG03-91ER61125
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
dna; complexes; dyes; designed; energy; transfer; fluorescent; markers; heteromultimeric; fluorophores; provided; binding; allow; detection; electrical; separations; preparation; probes; high-fluorescent; efficiencies; stokes; shifts; addition; appropriate; choice; molecules; single; narrow; wavelength; band; excitation; light; source; obtaining; emissions; sufficient; separation; readily; discriminated; stokes shifts; dyes designed; fluorescent molecules; single narrow; energy transfer; light source; excitation light; fluorescent emissions; wavelength band; narrow wavelength; readily discriminated; obtaining fluorescent; sufficient separation; electrical separations; dna complexes; high-fluorescent efficiencies; heteromultimeric fluorophores; fluorescent markers; band excitation; appropriate choice; fluorescent emission; stokes shift; /999/204/