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Title: Gene for ataxia-telangiectasia complementation group D (ATDC)

Disclosed herein is a new gene, an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for said gene are provided as well as proteins encoded by said gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of said proteins. Further disclosed are methods to detect mutations in said gene, preferably methods employing the polymerase chain reaction (PCR). Also disclosed are methods to detect AT genes from other AT complementation groups.
Inventors:
 [1];  [2];  [3];  [4]
  1. (San Francisco, CA)
  2. (Burlingame, CA)
  3. (San Rafael, CA)
  4. (Redwood City, CA)
Issue Date:
OSTI Identifier:
869776
Assignee:
Regents of University of California (California, CA) OAK
Patent Number(s):
US 5395767
Contract Number:
W-7405-ENG-48; AC03-76SF01012
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
ataxia-telangiectasia; complementation; atdc; disclosed; fragments; nucleic; acid; probes; provided; proteins; encoded; cdna; therefrom; preferably; kilobase; kb; recombinant; molecules; expression; methods; detect; mutations; employing; polymerase; chain; reaction; pcr; genes; acid molecule; chain reaction; acid probes; acid molecules; nucleic acid; polymerase chain; acid probe; methods employing; methods employ; /435/999/