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Title: Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.
 [1];  [2];  [3];  [3]
  1. (Germantown, MD)
  2. (Superior, CO)
  3. (Grand Junction, CO)
Issue Date:
OSTI Identifier:
University of California Office of Technology Transfer (Alameda, CA) LANL
Patent Number(s):
US 5391547
Contract Number:
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM
Country of Publication:
United States
method; 10; 15; 20-tetrakis; 4-carboxyphenyl; porphine; treating; cancers; lung; tetra-aryl; porphyrins; particular; fluorescent; tracer; radiotracer; complex; 67; cu; latter; provides; source; beta; radiation; selective; destruction; malignancies; gamma; useful; image; analysis; situs; single; photon; emission; computed; tomography; example; vivo; copper-64; substituted; characteristics; lighter; isotope; copper; positron; emitter; techniques; locate; malignant; tissue; mass; computed tomography; gamma radiation; emission tomography; positron emission; photon emission; beta radiation; single photon; emission computed; tomography techniques; positron emitter; tissue mass; image analysis; tetra-aryl porphyrins; fluorescent tracer; malignant tissue; /514/424/