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Title: Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung

Abstract

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.

Inventors:
 [1];  [2];  [3];  [3]
+ Show Inventor Affiliations
  1. Germantown, MD
  2. (Superior, CO)
  3. Grand Junction, CO
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
OSTI Identifier:
869755
Patent Number(s):
5391547
Assignee:
University of California Office of Technology Transfer (Alameda, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; 10; 15; 20-tetrakis; 4-carboxyphenyl; porphine; treating; cancers; lung; tetra-aryl; porphyrins; particular; fluorescent; tracer; radiotracer; complex; 67; cu; latter; provides; source; beta; radiation; selective; destruction; malignancies; gamma; useful; image; analysis; situs; single; photon; emission; computed; tomography; example; vivo; copper-64; substituted; characteristics; lighter; isotope; copper; positron; emitter; techniques; locate; malignant; tissue; mass; computed tomography; gamma radiation; emission tomography; positron emission; photon emission; beta radiation; single photon; emission computed; tomography techniques; positron emitter; tissue mass; image analysis; tetra-aryl porphyrins; fluorescent tracer; malignant tissue; /514/424/

Citation Formats

Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, and Klein, M Gerard. Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung. United States: N. p., 1995. Web.
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Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, & Klein, M Gerard. Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung. United States.
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Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, and Klein, M Gerard. Sun . "Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung". United States. https://www.osti.gov/servlets/purl/869755.
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@article{osti_869755,
title = {Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung},
author = {Cole, Dean A and Moody, III, David C. and Ellinwood, L Edward and Klein, M Gerard},
abstractNote = {Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {1}
}
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Works referenced in this record:

Preparation and characterization of copper-67 porphyrin-antibody conjugates
journal, December 1987

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