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Title: Synthesis of oxazolines and oxazines

Abstract

A process of preparing an oxazoline or oxazine compound of the formula ##STR1## wherein X is an atom selected from the group of oxygen and sulfur, R is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 fluoroalkyl, aryl and substituted-aryl, and n is 2 or 3 comprising ring-closing a compound of the formula ##STR2## wherein X is an atom selected from the group of oxygen and sulfur, R is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 fluoroalkyl, aryl, and substituted aryl, n is 2 or 3, and Y is a bromine or chlorine atom in the presence of a basic reagent consisting essentially of a fluoride salt supported on an inorganic solid substrate is disclosed together with the compounds, 5-bromomethyl-2-phenyl-1,3-oxazoline, 5-methylene-2-phenyl-1,3-oxazine and 4,4-dimethyl-2-vinyl-1,3-oxazoline.

Inventors:
 [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM
OSTI Identifier:
869711
Patent Number(s):
5382665
Assignee:
United States of America as represented by United States (Washington, DC)
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
synthesis; oxazolines; oxazines; process; preparing; oxazoline; oxazine; compound; formula; str1; atom; selected; oxygen; sulfur; consisting; 1-10; alkyl; fluoroalkyl; aryl; substituted-aryl; comprising; ring-closing; str2; substituted; bromine; chlorine; presence; basic; reagent; essentially; fluoride; salt; supported; inorganic; solid; substrate; disclosed; compounds; 5-bromomethyl-2-phenyl-1; 3-oxazoline; 5-methylene-2-phenyl-1; 3-oxazine; 4-dimethyl-2-vinyl-1; atom selected; consisting essentially; fluoride salt; solid substrate; chlorine atom; organic solid; oxazine compound; /999/

Citation Formats

Benicewicz, Brian C, and Mitchell, Michael A. Synthesis of oxazolines and oxazines. United States: N. p., 1995. Web.
Benicewicz, Brian C, & Mitchell, Michael A. Synthesis of oxazolines and oxazines. United States.
Benicewicz, Brian C, and Mitchell, Michael A. Sun . "Synthesis of oxazolines and oxazines". United States. https://www.osti.gov/servlets/purl/869711.
@article{osti_869711,
title = {Synthesis of oxazolines and oxazines},
author = {Benicewicz, Brian C and Mitchell, Michael A},
abstractNote = {A process of preparing an oxazoline or oxazine compound of the formula ##STR1## wherein X is an atom selected from the group of oxygen and sulfur, R is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 fluoroalkyl, aryl and substituted-aryl, and n is 2 or 3 comprising ring-closing a compound of the formula ##STR2## wherein X is an atom selected from the group of oxygen and sulfur, R is selected from the group consisting of C.sub.1-10 alkyl, C.sub.1-10 fluoroalkyl, aryl, and substituted aryl, n is 2 or 3, and Y is a bromine or chlorine atom in the presence of a basic reagent consisting essentially of a fluoride salt supported on an inorganic solid substrate is disclosed together with the compounds, 5-bromomethyl-2-phenyl-1,3-oxazoline, 5-methylene-2-phenyl-1,3-oxazine and 4,4-dimethyl-2-vinyl-1,3-oxazoline.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1995},
month = {1}
}

Patent:

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