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Title: Substituted 6-nitroquipazines, methods of preparation, and methods of use

Abstract

Disclosed is a substituted 6-nitroquipazine of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each selected from the group consisting of H, Fl, CL, Br, I, CF.sub.3, CH.sub.2 CH.sub.2 F, CH.sub.3, CH.sub.2 CH.sub.3, and --CH(CH.sub.3).sub.2, and wherein one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is other than H. Also disclosed is a method for measurement of serotonin uptake sites in a sample, in which a radioligand is incubated with a sample and then the radioactivity of the radioligand bound to the sample is determined, utilizing a radio labeled substituted 6-nitroquipazine as the radioligand. Also disclosed is a method of manufacture and method of use.

Inventors:
 [1];  [2];  [3];  [4]
  1. (Pittsburgh, PA)
  2. Rohovot, IL
  3. Pleasant Hill, CA
  4. Pittsburg, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
869645
Patent Number(s):
5372813
Assignee:
Regents, University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
substituted; 6-nitroquipazines; methods; preparation; disclosed; 6-nitroquipazine; formula; str1; rsub1; rsub2; rsub3; rsub4; selected; consisting; fl; br; cfsub3; chsub2; chsub3; -chchsub3sub2; method; measurement; serotonin; uptake; sites; sample; radioligand; incubated; radioactivity; bound; determined; utilizing; radio; labeled; manufacture; serotonin uptake sites; radio labeled; /424/436/999/

Citation Formats

Mathis, Jr., Chester A., Biegon, Anat, Taylor, Scott E, and Enas, Joel D. Substituted 6-nitroquipazines, methods of preparation, and methods of use. United States: N. p., 1994. Web.
Mathis, Jr., Chester A., Biegon, Anat, Taylor, Scott E, & Enas, Joel D. Substituted 6-nitroquipazines, methods of preparation, and methods of use. United States.
Mathis, Jr., Chester A., Biegon, Anat, Taylor, Scott E, and Enas, Joel D. Sat . "Substituted 6-nitroquipazines, methods of preparation, and methods of use". United States. https://www.osti.gov/servlets/purl/869645.
@article{osti_869645,
title = {Substituted 6-nitroquipazines, methods of preparation, and methods of use},
author = {Mathis, Jr., Chester A. and Biegon, Anat and Taylor, Scott E and Enas, Joel D},
abstractNote = {Disclosed is a substituted 6-nitroquipazine of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each selected from the group consisting of H, Fl, CL, Br, I, CF.sub.3, CH.sub.2 CH.sub.2 F, CH.sub.3, CH.sub.2 CH.sub.3, and --CH(CH.sub.3).sub.2, and wherein one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is other than H. Also disclosed is a method for measurement of serotonin uptake sites in a sample, in which a radioligand is incubated with a sample and then the radioactivity of the radioligand bound to the sample is determined, utilizing a radio labeled substituted 6-nitroquipazine as the radioligand. Also disclosed is a method of manufacture and method of use.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

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