Process for the separation and purification of yttrium-90 for medical applications

Title: Process for the separation and purification of yttrium-90 for medical applications

Abstract

An extraction chromatographic method for the preparation of .sup.90 Y of high chemical and radiochemical purity is disclosed. After an initial purification of a .sup.90 Sr stock solution and a suitable period of .sup.90 Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the .sup.90 Sr content of the mixture by a factor of about 10.sup.3. The .sup.90 Y remaining is freed from any residual .sup.90 Sr, from its .sup.90 Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium.

Inventors:

Horwitz, Philip E ^[1]; Dietz, Mark L ^[2]

Naperville, IL
Evanston, IL

Issue Date:: 1994-01-01

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States)

OSTI Identifier:: 869624

Patent Number(s):: 5368736

Assignee:: United States of America as represented by United States (Washington, DC)

Patent Classifications (CPCs):: C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

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C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS
C22B59/00 - Obtaining rare earth metals

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}
G21G1/001 - {Recovery of specific isotopes from irradiated targets}

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01F - COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
C01F17/13 - by using ion exchange resins, e.g. chelate resins
C01F17/10 - Preparation or treatment, e.g. separation or purification

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DOE Contract Number:: W-31109-ENG-38

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: process; separation; purification; yttrium-90; medical; applications; extraction; chromatographic; method; preparation; 90; chemical; radiochemical; purity; disclosed; initial; sr; stock; solution; suitable; period; ingrowth; passed; series; strontium-selective; columns; lowers; content; mixture; factor; 10; remaining; freed; residual; zr; daughter; impurities; passing; sample; final; column; designed; selectively; retain; yttrium; medical applications; chromatographic column; extraction chromatographic; /210/423/

Citation Formats


                    Horwitz, Philip E, and Dietz, Mark L. Process for the separation and purification of yttrium-90 for medical applications.  United States: N. p., 1994. 
        Web.

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                    Horwitz, Philip E, & Dietz, Mark L. Process for the separation and purification of yttrium-90 for medical applications.  United States.

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                    Horwitz, Philip E, and Dietz, Mark L. Sat .  
        "Process for the separation and purification of yttrium-90 for medical applications".  United States.  https://www.osti.gov/servlets/purl/869624.

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@article{osti_869624,

  title        = {Process for the separation and purification of yttrium-90 for medical applications},

  author       = {Horwitz, Philip E and Dietz, Mark L},

  abstractNote = {An extraction chromatographic method for the preparation of .sup.90 Y of high chemical and radiochemical purity is disclosed. After an initial purification of a .sup.90 Sr stock solution and a suitable period of .sup.90 Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the .sup.90 Sr content of the mixture by a factor of about 10.sup.3. The .sup.90 Y remaining is freed from any residual .sup.90 Sr, from its .sup.90 Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1994},

  month        = {1}

}

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Works referenced in this record:

The preparation of a rubidium-82 radionuclide generator
journal, March 1981

Horlock, P. L.; Clark, J. C.; Goodier, I. W.
Journal of Radioanalytical Chemistry, Vol. 64, Issue 1-2
https://doi.org/10.1007/BF02518356

Chemistry for commercial scale production of yttrium-90 for medical research
journal, January 1990

Wike, J. S.; Guyer, C. E.; Ramey, D. W.
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 9
https://doi.org/10.1016/0883-2889(90)90064-N

Improved chemistry for the production of yttrium-90 for medical applications
journal, September 1992

Dietz, Mark L.; Horwitz, E. Philip
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 9
https://doi.org/10.1016/0883-2889(92)90050-O

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Title: Process for the separation and purification of yttrium-90 for medical applications

Abstract

Citation Formats

The preparation of a rubidium-82 radionuclide generator journal, March 1981

Chemistry for commercial scale production of yttrium-90 for medical research journal, January 1990

Improved chemistry for the production of yttrium-90 for medical applications journal, September 1992

The preparation of a rubidium-82 radionuclide generator
journal, March 1981

Chemistry for commercial scale production of yttrium-90 for medical research
journal, January 1990

Improved chemistry for the production of yttrium-90 for medical applications
journal, September 1992