Process for the separation and purification of yttrium-90 for medical applications
Abstract
An extraction chromatographic method for the preparation of .sup.90 Y of high chemical and radiochemical purity is disclosed. After an initial purification of a .sup.90 Sr stock solution and a suitable period of .sup.90 Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the .sup.90 Sr content of the mixture by a factor of about 10.sup.3. The .sup.90 Y remaining is freed from any residual .sup.90 Sr, from its .sup.90 Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium.
- Inventors:
-
- Naperville, IL
- Evanston, IL
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- OSTI Identifier:
- 869624
- Patent Number(s):
- 5368736
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01F - COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS
- DOE Contract Number:
- W-31109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- process; separation; purification; yttrium-90; medical; applications; extraction; chromatographic; method; preparation; 90; chemical; radiochemical; purity; disclosed; initial; sr; stock; solution; suitable; period; ingrowth; passed; series; strontium-selective; columns; lowers; content; mixture; factor; 10; remaining; freed; residual; zr; daughter; impurities; passing; sample; final; column; designed; selectively; retain; yttrium; medical applications; chromatographic column; extraction chromatographic; /210/423/
Citation Formats
Horwitz, Philip E, and Dietz, Mark L. Process for the separation and purification of yttrium-90 for medical applications. United States: N. p., 1994.
Web.
Horwitz, Philip E, & Dietz, Mark L. Process for the separation and purification of yttrium-90 for medical applications. United States.
Horwitz, Philip E, and Dietz, Mark L. Sat .
"Process for the separation and purification of yttrium-90 for medical applications". United States. https://www.osti.gov/servlets/purl/869624.
@article{osti_869624,
title = {Process for the separation and purification of yttrium-90 for medical applications},
author = {Horwitz, Philip E and Dietz, Mark L},
abstractNote = {An extraction chromatographic method for the preparation of .sup.90 Y of high chemical and radiochemical purity is disclosed. After an initial purification of a .sup.90 Sr stock solution and a suitable period of .sup.90 Y ingrowth, the solution is passed through a series of strontium-selective chromatographic columns, each of which lowers the .sup.90 Sr content of the mixture by a factor of about 10.sup.3. The .sup.90 Y remaining is freed from any residual .sup.90 Sr, from its .sup.90 Zr daughter, and from any remaining impurities by passing the sample through a final column designed to selectively retain yttrium.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}
Works referenced in this record:
The preparation of a rubidium-82 radionuclide generator
journal, March 1981
- Horlock, P. L.; Clark, J. C.; Goodier, I. W.
- Journal of Radioanalytical Chemistry, Vol. 64, Issue 1-2
Chemistry for commercial scale production of yttrium-90 for medical research
journal, January 1990
- Wike, J. S.; Guyer, C. E.; Ramey, D. W.
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 9
Improved chemistry for the production of yttrium-90 for medical applications
journal, September 1992
- Dietz, Mark L.; Horwitz, E. Philip
- International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 9