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Title: Method for detection of long-lived radioisotopes in small biochemical samples

Abstract

Disclosed is a method for detection of long-lived radioisotopes in small bio-chemical samples, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biologist host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

Inventors:
 [1];  [2];  [3];  [4];  [1]
  1. Livermore, CA
  2. Union City, CA
  3. Danville, CA
  4. Alamo, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
869613
Patent Number(s):
5366721
Assignee:
Regents of University of California (Oakland, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; detection; long-lived; radioisotopes; biochemical; samples; disclosed; bio-chemical; comprising; selecting; biological; host; concentrations; equal; ambient; biosphere; preparing; radioisotope; labeled; reactive; chemical; specie; administering; biologist; doses; sufficiently; avoid; significant; overt; damage; allowing; period; time; elapse; sufficient; dissemination; interaction; throughout; isolating; reacted; fraction; substance; manner; contamination; extraneous; sources; converting; suitable; means; material; efficiently; produces; charged; introduction; isotopic; fractionation; measuring; concentration; direct; counting; reactive chemical; suitable means; avoid contamination; biological substance; biological host; chemical specie; reacted fraction; radioisotope labeled; radioisotope concentration; significant isotopic; significant overt; avoid significant; ambient biosphere; produces charged; manner sufficient; isotopic counting; overt damage; concentrations equal; isotopic fractionation; long-lived radioisotope; extraneous sources; direct isotopic; efficiently produces; elapse sufficient; labeled reactive; doses sufficiently; host throughout; active chemical; long-lived radioisotopes; isotope concentration; /424/436/600/

Citation Formats

Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, and Davis, Jay C. Method for detection of long-lived radioisotopes in small biochemical samples. United States: N. p., 1994. Web.
Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, & Davis, Jay C. Method for detection of long-lived radioisotopes in small biochemical samples. United States.
Turteltaub, Kenneth W, Vogel, John S, Felton, James S, Gledhill, Barton L, and Davis, Jay C. Sat . "Method for detection of long-lived radioisotopes in small biochemical samples". United States. https://www.osti.gov/servlets/purl/869613.
@article{osti_869613,
title = {Method for detection of long-lived radioisotopes in small biochemical samples},
author = {Turteltaub, Kenneth W and Vogel, John S and Felton, James S and Gledhill, Barton L and Davis, Jay C},
abstractNote = {Disclosed is a method for detection of long-lived radioisotopes in small bio-chemical samples, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biologist host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

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