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Title: Derivatized gold clusters and antibody-gold cluster conjugates

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.
Inventors:
 [1];  [2]
  1. (Shoreham, NY)
  2. (Williston Park, NY)
Issue Date:
OSTI Identifier:
869590
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5360895
Application Number:
07/988,338
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
derivatized; gold; clusters; antibody-gold; cluster; conjugates; antibody-; antibody; fragment-gold; shown; conjugate; size; nm; methods; reagents; disclosed; antibodies; fab; fragments; covalently; bound; stable; atoms; contain; 11; 13; 55; 67; inner; core; radioactive; antibody-cluster; useful; electron; microscopy; applications; clinical; imaging; diagnosis; therapy; inner core; covalently bound; antibody fragment; cluster conjugates; electron microscopy; /530/436/