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Title: Derivatized gold clusters and antibody-gold cluster conjugates

Abstract

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.

Inventors:
 [1];  [2]
  1. Shoreham, NY
  2. Williston Park, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
869590
Patent Number(s):
5360895
Application Number:
07/988,338
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
derivatized; gold; clusters; antibody-gold; cluster; conjugates; antibody-; antibody; fragment-gold; shown; conjugate; size; nm; methods; reagents; disclosed; antibodies; fab; fragments; covalently; bound; stable; atoms; contain; 11; 13; 55; 67; inner; core; radioactive; antibody-cluster; useful; electron; microscopy; applications; clinical; imaging; diagnosis; therapy; inner core; covalently bound; antibody fragment; cluster conjugates; electron microscopy; /530/436/

Citation Formats

Hainfeld, James F, and Furuya, Frederic R. Derivatized gold clusters and antibody-gold cluster conjugates. United States: N. p., 1994. Web.
Hainfeld, James F, & Furuya, Frederic R. Derivatized gold clusters and antibody-gold cluster conjugates. United States.
Hainfeld, James F, and Furuya, Frederic R. Tue . "Derivatized gold clusters and antibody-gold cluster conjugates". United States. https://www.osti.gov/servlets/purl/869590.
@article{osti_869590,
title = {Derivatized gold clusters and antibody-gold cluster conjugates},
author = {Hainfeld, James F and Furuya, Frederic R},
abstractNote = {Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {11}
}

Patent:

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