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Title: Method for microbeam radiation therapy

A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.
Inventors:
 [1];  [2];  [3]
  1. (Sound Beach, NY)
  2. (Yaphank, NY)
  3. (Shoreham, NY)
Issue Date:
OSTI Identifier:
869455
Assignee:
United States of America as represented by United States (Washington, DC) BNL
Patent Number(s):
US 5339347
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
method; microbeam; radiation; therapy; performing; patient; involving; exposing; target; tumor; therapeutic; dose; energy; electromagnetic; preferably; x-ray; form; non-overlapping; microbeams; width; millimeter; tissue; exposed; receives; exposure; exceeds; maximum; survive; non-target; below; threshold; amount; survived; permits; regenerate; directed; direction; overlap; enhancing; lethal; effect; irradiation; sparing; surrounding; healthy; target tissue; electromagnetic radiation; radiation dose; radiation therapy; x-ray radiation; beam radiation; ray radiation; performing radiation; /378/