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Title: Stable radiometal antibody immunoconjugates

The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.
Inventors:
 [1];  [2];  [3]
  1. (Coram, NY)
  2. (Setauket, NY)
  3. (Oudon, FR)
Issue Date:
OSTI Identifier:
869422
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5334729
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
stable; radiometal; antibody; immunoconjugates; relates; rigid; chelating; structures; methods; preparing; materials; labeled; chelates; cyclohexyl; edta; monohydride; trans; forms; dtpa; ttha; derivatives; polyaminocarboxylate; stable radiometal; radiometal antibody; radiometal labeled; rigid chelating; polyaminocarboxylate materials; preparing radiometal; chelating structures; cyclohexyl edta; antibody immunoconjugates; labeled immunoconjugates; cyclohexyl dtpa; edta monohydride; cyclohexyl polyaminocarboxylate; /999/