Radiopharmaceuticals for imaging the heart
Abstract
Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.
- Inventors:
- Issue Date:
- Research Org.:
- Purdue Univ., West Lafayette, IN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 869370
- Patent Number(s):
- 5324502
- Application Number:
- 07/861,778
- Assignee:
- Purdue Research Foundation (West Lafayette, IN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
- DOE Contract Number:
- FG02-89ER60868
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 1992 Apr 02
- Country of Publication:
- United States
- Language:
- English
- Subject:
- /424/999/
Citation Formats
Green, Mark A., and Tsang, Brenda W.. Radiopharmaceuticals for imaging the heart. United States: N. p., 1994.
Web.
Green, Mark A., & Tsang, Brenda W.. Radiopharmaceuticals for imaging the heart. United States.
Green, Mark A., and Tsang, Brenda W.. Sat .
"Radiopharmaceuticals for imaging the heart". United States. https://www.osti.gov/servlets/purl/869370.
@article{osti_869370,
title = {Radiopharmaceuticals for imaging the heart},
author = {Green, Mark A. and Tsang, Brenda W.},
abstractNote = {Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}
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- Polymer Bulletin, Vol. 11, Issue 2
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- Fritz, H. P.; Vit�, L. W. G.
- Zeitschrift f�r anorganische und allgemeine Chemie, Vol. 392, Issue 3