skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiopharmaceuticals for imaging the heart

Abstract

Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.

Inventors:
 [1];  [2]
  1. (West Lafayette, IN)
  2. (Lafayette, IN)
Issue Date:
Research Org.:
Purdue Research Foundation, Lafayette, IN (USA)
OSTI Identifier:
869370
Patent Number(s):
5324502
Assignee:
Purdue Research Foundation (West Lafayette, IN) CHO
DOE Contract Number:  
FG02-89ER60868
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
radiopharmaceuticals; imaging; heart; myocardial; tissues; prepared; forming; lipophilic; cationic; complexes; radioactive; metal; chelating; ligands; comprising; schiff; base; adducts; triamines; tetraamines; optionally; substituted; salicylaldehydes; exhibit; uptake; retention; preferred; gallium-68; iii; accordance; image; positron; emission; tomography; radioactive metal; metal chelating; active metal; emission tomography; positron emission; optionally substituted; schiff base; myocardial tissue; /424/999/

Citation Formats

Green, Mark A., and Tsang, Brenda W. Radiopharmaceuticals for imaging the heart. United States: N. p., 1994. Web.
Green, Mark A., & Tsang, Brenda W. Radiopharmaceuticals for imaging the heart. United States.
Green, Mark A., and Tsang, Brenda W. Sat . "Radiopharmaceuticals for imaging the heart". United States. https://www.osti.gov/servlets/purl/869370.
@article{osti_869370,
title = {Radiopharmaceuticals for imaging the heart},
author = {Green, Mark A. and Tsang, Brenda W.},
abstractNote = {Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

Patent:

Save / Share: