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Title: Catalytic and reactive polypeptides and methods for their preparation and use

Abstract

Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like. This invention was made with Government support under Grant Contract No. AI-24695, awarded by the Department of health and Human Services, and under Grant Contract No. N 00014-87-K-0256, awarded by the Office of Naval Research. The Government has certain rights in this invention.

Inventors:
 [1]
  1. (Oakland, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
869318
Patent Number(s):
5314817
Assignee:
Regents of University of California (Oakland, CA) LBNL
DOE Contract Number:  
C87-101226
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
catalytic; reactive; polypeptides; methods; preparation; binding; site; specific; reactant; intermediate; involved; chemical; reaction; active; functionality; proximate; capable; catalyzing; chemically; participating; rate; enhanced; preparing; peptides; synthesis; site-directed; mutagenesis; antibody; enzyme; genes; covalent; attachment; functionalities; particular; amino; acid; chains; government; support; grant; contract; ai-24695; awarded; department; health; human; services; 00014-87-k-0256; office; naval; rights; reactive polypeptides; chemical synthesis; active functionality; reaction rate; binding site; amino acid; chemical reaction; government support; reactive intermediate; site specific; functionality proximate; human services; intermediate involved; active poly; active polypeptide; /435/530/

Citation Formats

Schultz, Peter. Catalytic and reactive polypeptides and methods for their preparation and use. United States: N. p., 1994. Web.
Schultz, Peter. Catalytic and reactive polypeptides and methods for their preparation and use. United States.
Schultz, Peter. Sat . "Catalytic and reactive polypeptides and methods for their preparation and use". United States. https://www.osti.gov/servlets/purl/869318.
@article{osti_869318,
title = {Catalytic and reactive polypeptides and methods for their preparation and use},
author = {Schultz, Peter},
abstractNote = {Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like. This invention was made with Government support under Grant Contract No. AI-24695, awarded by the Department of health and Human Services, and under Grant Contract No. N 00014-87-K-0256, awarded by the Office of Naval Research. The Government has certain rights in this invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

Patent:

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