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Title: Raman-based system for DNA sequencing-mapping and other separations

Abstract

DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.

Inventors:
 [1]
  1. (Knoxville, TN)
Issue Date:
Research Org.:
LOCKHEED MARTIN ENRGY SYST INC
OSTI Identifier:
869250
Patent Number(s):
5306403
Assignee:
Martin Marietta Energy Systems, Inc. (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
raman-based; dna; sequencing-mapping; separations; sequencing; mapping; performed; raman; spectrometer; surface; enhanced; scattering; sers; substrate; enhance; signal; label; attached; fragment; analyzed; identify; according; characteristics; spectrum; generated; sers label; raman scattering; dna sequencing; enhanced raman; surface enhanced; dna fragment; raman spectrum; raman signal; /204/73/

Citation Formats

Vo-Dinh, Tuan. Raman-based system for DNA sequencing-mapping and other separations. United States: N. p., 1994. Web.
Vo-Dinh, Tuan. Raman-based system for DNA sequencing-mapping and other separations. United States.
Vo-Dinh, Tuan. Sat . "Raman-based system for DNA sequencing-mapping and other separations". United States. https://www.osti.gov/servlets/purl/869250.
@article{osti_869250,
title = {Raman-based system for DNA sequencing-mapping and other separations},
author = {Vo-Dinh, Tuan},
abstractNote = {DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

Patent:

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