Raman-based system for DNA sequencing-mapping and other separations
Abstract
DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 869250
- Patent Number(s):
- 5306403
- Assignee:
- Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- raman-based; dna; sequencing-mapping; separations; sequencing; mapping; performed; raman; spectrometer; surface; enhanced; scattering; sers; substrate; enhance; signal; label; attached; fragment; analyzed; identify; according; characteristics; spectrum; generated; sers label; raman scattering; dna sequencing; enhanced raman; surface enhanced; dna fragment; raman spectrum; raman signal; /204/73/
Citation Formats
Vo-Dinh, Tuan. Raman-based system for DNA sequencing-mapping and other separations. United States: N. p., 1994.
Web.
Vo-Dinh, Tuan. Raman-based system for DNA sequencing-mapping and other separations. United States.
Vo-Dinh, Tuan. Sat .
"Raman-based system for DNA sequencing-mapping and other separations". United States. https://www.osti.gov/servlets/purl/869250.
@article{osti_869250,
title = {Raman-based system for DNA sequencing-mapping and other separations},
author = {Vo-Dinh, Tuan},
abstractNote = {DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}
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