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Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.

Inventors:
 [1];  [1];  [1]
  1. Pittsburgh, PA
Issue Date:
Research Org.:
University of Pittsburgh
OSTI Identifier:
869193
Patent Number(s):
5294715
Assignee:
University of Pittsburgh (Pittsburgh, PA)
DOE Contract Number:  
FG02-89ER60869
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
acridine-intercalator; based; hypoxia; selective; cytotoxins; formula; str1; 5-positions; imidazole; compounds; utility; radiosensitizers; chemosensitizers; selective cytotoxins; hypoxia selective; /999/

Citation Formats

Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins. United States: N. p., 1994. Web.
Papadopoulou-Rosenzweig, Maria, Bloomer, William D, & Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins. United States.
Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Sat . "Acridine-intercalator based hypoxia selective cytotoxins". United States. https://www.osti.gov/servlets/purl/869193.
@article{osti_869193,
title = {Acridine-intercalator based hypoxia selective cytotoxins},
author = {Papadopoulou-Rosenzweig, Maria and Bloomer, William D and Bloomer, William D},
abstractNote = {Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

Patent:

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