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Title: Acridine-intercalator based hypoxia selective cytotoxins

Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.
Inventors:
 [1];  [1];  [1]
  1. (Pittsburgh, PA)
Issue Date:
OSTI Identifier:
869193
Assignee:
University of Pittsburgh (Pittsburgh, PA) CHO
Patent Number(s):
US 5294715
Contract Number:
FG02-89ER60869
Research Org:
University of Pittsburgh
Country of Publication:
United States
Language:
English
Subject:
acridine-intercalator; based; hypoxia; selective; cytotoxins; formula; str1; 5-positions; imidazole; compounds; utility; radiosensitizers; chemosensitizers; selective cytotoxins; hypoxia selective; /999/