Acridine-intercalator based hypoxia selective cytotoxins

Papadopoulou-Rosenzweig, Maria; Bloomer, William D; Bloomer, William D

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Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.

Inventors:

Papadopoulou-Rosenzweig, Maria ^[1]; Bloomer, William D ^[1]; Bloomer, William D ^[1]

Pittsburgh, PA

Issue Date:: 1994-01-01

Research Org.:: Univ. of Pittsburgh, PA (United States)

OSTI Identifier:: 869193

Patent Number(s):: 5294715

Assignee:: University of Pittsburgh (Pittsburgh, PA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D401/12 - linked by a chain containing hetero atoms as chain links

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DOE Contract Number:: FG02-89ER60869

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: acridine-intercalator; based; hypoxia; selective; cytotoxins; formula; str1; 5-positions; imidazole; compounds; utility; radiosensitizers; chemosensitizers; selective cytotoxins; hypoxia selective; /999/

Citation Formats


                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins.  United States: N. p., 1994. 
        Web.

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                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, & Bloomer, William D. Acridine-intercalator based hypoxia selective cytotoxins.  United States.

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                    Papadopoulou-Rosenzweig, Maria, Bloomer, William D, and Bloomer, William D. Sat .  
        "Acridine-intercalator based hypoxia selective cytotoxins".  United States.  https://www.osti.gov/servlets/purl/869193.

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@article{osti_869193,

  title        = {Acridine-intercalator based hypoxia selective cytotoxins},

  author       = {Papadopoulou-Rosenzweig, Maria and Bloomer, William D and Bloomer, William D},

  abstractNote = {Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1994},

  month        = {1}

}

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Works referenced in this record:

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Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands
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Similar Records

Title: Acridine-intercalator based hypoxia selective cytotoxins

Abstract

Citation Formats

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo journal, May 1984

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation journal, January 1992

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen journal, April 1983

A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2 journal, July 1986

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508 journal, September 1984

Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo journal, January 1989

High-Pressure Oxygen and Radiotherapy journal, May 1955

Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl 2 (ANT) 2 ], Affects DNA Binding, Toxicity and Radiosensitizing Ability journal, January 1987

Chemotherapy of Cancer journal, March 1978

Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles journal, January 1987

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands journal, August 1984

Reductive metabolism and hypoxia-selective toxicity of nitracrine journal, July 1986

Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator journal, January 1987

Enhancement of chemotherapy agents journal, March 1982

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations journal, September 1984

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799 journal, September 1984

Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo journal, July 1986

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B. journal, November 1956

Third International Meeting on Progress in Radio-Oncology journal, January 1985

The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds journal, April 1985

NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin journal, April 1989

Selective toxicity of nitracrine to hypoxic mammalian cells journal, February 1984

Radiation and Platinum Drug Interaction journal, January 1985

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay journal, April 1989

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines journal, August 1990

Radiosensitization of EMT6 cells by four platinum complexes journal, May 1985

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo
journal, May 1984

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation
journal, January 1992

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen
journal, April 1983

A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2
journal, July 1986

Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508
journal, September 1984

Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo
journal, January 1989

High-Pressure Oxygen and Radiotherapy
journal, May 1955

Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl ₂ (ANT) ₂ ], Affects DNA Binding, Toxicity and Radiosensitizing Ability
journal, January 1987

Chemotherapy of Cancer
journal, March 1978

Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles
journal, January 1987

Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands
journal, August 1984

Reductive metabolism and hypoxia-selective toxicity of nitracrine
journal, July 1986

Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator
journal, January 1987

Enhancement of chemotherapy agents
journal, March 1982

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations
journal, September 1984

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799
journal, September 1984

Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo
journal, July 1986

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B.
journal, November 1956

Third International Meeting on Progress in Radio-Oncology
journal, January 1985

The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds
journal, April 1985

NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin
journal, April 1989

Selective toxicity of nitracrine to hypoxic mammalian cells
journal, February 1984

Radiation and Platinum Drug Interaction
journal, January 1985

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay
journal, April 1989

Radiosensitization of Mammalian Cells in Vitro by Nitroacridines
journal, August 1990

Radiosensitization of EMT6 cells by four platinum complexes
journal, May 1985