skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Abstract

Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.

Inventors:
 [1];  [2];  [3]
  1. Coram, NY
  2. Stony Brook, NY
  3. Setauket, NY
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
869181
Patent Number(s):
5292938
Assignee:
Associated Universities, Inc. (Washington, DC)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclo; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /999/530/

Citation Formats

Mease, Ronnie C, Mausner, Leonard F, and Srivastava, Suresh C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States: N. p., 1994. Web.
Mease, Ronnie C, Mausner, Leonard F, & Srivastava, Suresh C. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging. United States.
Mease, Ronnie C, Mausner, Leonard F, and Srivastava, Suresh C. Sat . "Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging". United States. https://www.osti.gov/servlets/purl/869181.
@article{osti_869181,
title = {Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging},
author = {Mease, Ronnie C and Mausner, Leonard F and Srivastava, Suresh C},
abstractNote = {Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {1}
}

Patent:

Save / Share: