Global to push GA events into
skip to main content

Title: Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.
Inventors:
 [1];  [2];  [3]
  1. (Coram, NY)
  2. (Stony Brook, NY)
  3. (Setauket, NY)
Issue Date:
OSTI Identifier:
869181
Assignee:
Associated Universities, Inc. (Washington, DC) BNL
Patent Number(s):
US 5292938
Contract Number:
AC02-76CH00016
Research Org:
ASSOC UNIVERSITIES INC
Country of Publication:
United States
Language:
English
Subject:
synthesis; 4-substituted-trans-1; 2-diaminocyclohexyl; polyaminocarboxylate; metal; chelating; agents; preparation; stable; radiometal; antibody; immunoconjugates; therapy; spect; pet; imaging; cyclo; useful; forming; antibody-metal; conjugates; diagnostic; therapeutic; purposes; compounds; processes; disclosed; including; 4-haloacetamido-trans-1; 4-isothiocyanato-trans-1; 2-diamino; cyclohexane-n; -tetra; acetic; acid; therapeutic purposes; metal chelating; stable radiometal; radiometal antibody; acetic acid; chelating agents; chelating agent; disclosed including; pet imaging; antibody immunoconjugates; agents useful; cyclohexyl polyaminocarboxylate; forming antibody-metal; polyaminocarboxylate metal; /999/530/