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Title: Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline

Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.
 [1];  [2]
  1. (Danville, CA)
  2. (Livermore, CA)
Issue Date:
OSTI Identifier:
United States of America as represented by United States (Washington, DC) LLNL
Patent Number(s):
US 5283336
Contract Number:
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Country of Publication:
United States
method; preparation; 7-hydroxy-1234-tetrahydroquinoline; 1234-tetrahydroquinoline; methods; efficient; acylation; m-aminophenol; obtains; lactam; reduced; desired; quinoline; tetrahydroquinoline; nitrated; hydrogenated; hydrolyzed; obtain; desire; synthesis; lasing; dyes; rhodamine; lasing dyes; /999/