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Title: Methods and apparatus for analysis of chromatographic migration patterns

Abstract

A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.

Inventors:
 [1];  [1]
  1. (Salt Lake City, UT)
Issue Date:
Research Org.:
University of Utah
OSTI Identifier:
869094
Patent Number(s):
5273632
Assignee:
University of Utah Research Foundation (Salt Lake City, UT) CHO
DOE Contract Number:  
FG02-88ER60700
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
methods; apparatus; analysis; chromatographic; migration; patterns; method; sharpening; signal; peaks; representing; distribution; biological; chemical; components; mixture; separated; technique; limited; electrophoresis; key; step; blind; deconvolution; presently; embodied; homomorphic; filtering; reduce; contribution; blurring; function; encoding; steps; directed; determination; nucleotide; sequence; set; signals; dna; data; derived; electrophoretic; means; signals representing; signal representing; dna sequence; nucleotide sequence; chemical components; data derived; chemical component; mixture separated; signal peak; /204/210/436/702/

Citation Formats

Stockham, Thomas G., and Ives, Jeffrey T. Methods and apparatus for analysis of chromatographic migration patterns. United States: N. p., 1993. Web.
Stockham, Thomas G., & Ives, Jeffrey T. Methods and apparatus for analysis of chromatographic migration patterns. United States.
Stockham, Thomas G., and Ives, Jeffrey T. Fri . "Methods and apparatus for analysis of chromatographic migration patterns". United States. https://www.osti.gov/servlets/purl/869094.
@article{osti_869094,
title = {Methods and apparatus for analysis of chromatographic migration patterns},
author = {Stockham, Thomas G. and Ives, Jeffrey T.},
abstractNote = {A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

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