Methods and apparatus for analysis of chromatographic migration patterns
Abstract
A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.
- Inventors:
-
- Salt Lake City, UT
- Issue Date:
- Research Org.:
- Univ. of Utah, Salt Lake City, UT (United States)
- OSTI Identifier:
- 869094
- Patent Number(s):
- 5273632
- Assignee:
- University of Utah Research Foundation (Salt Lake City, UT)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- FG02-88ER60700
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- methods; apparatus; analysis; chromatographic; migration; patterns; method; sharpening; signal; peaks; representing; distribution; biological; chemical; components; mixture; separated; technique; limited; electrophoresis; key; step; blind; deconvolution; presently; embodied; homomorphic; filtering; reduce; contribution; blurring; function; encoding; steps; directed; determination; nucleotide; sequence; set; signals; dna; data; derived; electrophoretic; means; signals representing; signal representing; dna sequence; nucleotide sequence; chemical components; data derived; chemical component; mixture separated; signal peak; /204/210/436/702/
Citation Formats
Stockham, Thomas G, and Ives, Jeffrey T. Methods and apparatus for analysis of chromatographic migration patterns. United States: N. p., 1993.
Web.
Stockham, Thomas G, & Ives, Jeffrey T. Methods and apparatus for analysis of chromatographic migration patterns. United States.
Stockham, Thomas G, and Ives, Jeffrey T. Fri .
"Methods and apparatus for analysis of chromatographic migration patterns". United States. https://www.osti.gov/servlets/purl/869094.
@article{osti_869094,
title = {Methods and apparatus for analysis of chromatographic migration patterns},
author = {Stockham, Thomas G and Ives, Jeffrey T},
abstractNote = {A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1993},
month = {Fri Jan 01 00:00:00 EST 1993}
}
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Works referenced in this record:
Blind deconvolution through digital signal processing
journal, January 1975
- Stockham, T. G.; Cannon, T. M.; Ingebretsen, R. B.
- Proceedings of the IEEE, Vol. 63, Issue 4