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Title: Method for sequencing DNA base pairs

Abstract

The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources, each source being selected to preferentially excite one of the four different bases in the DNA structure. Each particular base being scanned is subjected to such sequence of infrared radiation from the four different sources as that particular base is being scanned. The DNA structure as a whole is separately imaged for each subjection thereof to radiation from one only of each source.

Inventors:
 [1];  [2]
  1. Oakland, CA
  2. Pacific Palisades, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
869068
Patent Number(s):
5270214
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; sequencing; dna; base; pairs; structure; sequenced; scanning; tunneling; microscope; stm; scanned; probe; tip; separately; subjected; sequence; infrared; radiation; sources; source; selected; preferentially; excite; bases; particular; imaged; subjection; scanning tunneling; sequencing dna; tunneling microscope; probe tip; infrared radiation; dna structure; base pairs; base pair; preferentially excite; /436/250/

Citation Formats

Sessler, Andrew M, and Dawson, John. Method for sequencing DNA base pairs. United States: N. p., 1993. Web.
Sessler, Andrew M, & Dawson, John. Method for sequencing DNA base pairs. United States.
Sessler, Andrew M, and Dawson, John. Fri . "Method for sequencing DNA base pairs". United States. https://www.osti.gov/servlets/purl/869068.
@article{osti_869068,
title = {Method for sequencing DNA base pairs},
author = {Sessler, Andrew M and Dawson, John},
abstractNote = {The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources, each source being selected to preferentially excite one of the four different bases in the DNA structure. Each particular base being scanned is subjected to such sequence of infrared radiation from the four different sources as that particular base is being scanned. The DNA structure as a whole is separately imaged for each subjection thereof to radiation from one only of each source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

Patent:

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